Pab pawg kho mob Azvudine rau kev kho tus kabmob tshiab yog tus thawj coj los ntawm Genuine Biotech. Suav Academy ntawm Kev Tshawb Fawb Txog Kev Kho Mob yog lub luag haujlwm rau kev kho tshuaj, kev ua tau zoo, thiab kev tshawb fawb pharmacokinetic. Ntawm lawv, Academician Wang Chen, Thawj Tswj Hwm ntawm Suav Academy ntawm Kev Tshawb Fawb Kev Kho Mob, yog lub luag haujlwm rau kev tshawb fawb soj ntsuam, Tsev Kho Mob Beijing Ditan, Tsev Kho Mob Wuhan Zhongnan, thiab lwm yam. 10 Ntau lub tsev kho mob tau koom nrog.
1. Ua ntej, azvudine ua haujlwm zoo.
Thaum Lub Ob Hlis 2020, Azvudine tau pom tias muaj peev xwm tiv taus tus kabmob tshiab no, thiab nws tau pom zoo rau Phase III kev sim tshuaj nyob rau lub Plaub Hlis 2020. Tam sim no tias Phase III kev sim tshuaj tau dhau lawm, qee qhov txiaj ntsig peb tau pom yog qhov zoo.
Cov txiaj ntsig kho mob ntawm azvudine yog raws li hauv qab no. Feem ntau, cov nucleic acid hloov tsis zoo tom qab 3-4 hnub ntawm kev tswj qhov ncauj. Kwv yees li 300 txog 400 tus neeg tau ua tiav nyob rau theem thib ob ntawm kev sim tshuaj, thiab ntau dua 800 tus neeg tau ua tiav nyob rau theem thib peb ntawm kev sim tshuaj. Los ntawm cov txiaj ntsig ntawm Phase II kev kho mob thiab qee qhov kev sim Phase III, peb tuaj yeem pom tias cov nucleic acid hloov tsis zoo li ntawm 3-4 hnub. Cov tshuaj tuaj yeem nres tom qab 6-7 hnub, thiab feem ntau tso tawm tsis pub dhau 9 hnub.
Thiab nws tsis muaj teeb meem txawm tias tus neeg mob tau noj tshuaj ua ntej, lossis tau noj tshuaj ib ntus, nws tseem tuaj yeem siv azvudine. Azvudine tsis zoo li qee cov tshuaj uas yuav tsum tau noj thaum ntxov ntawm tus kab mob tshiab coronary pneumonia, nws tsis xav tau. Yog li ntawd, cov txiaj ntsig ntawm cov tshuaj hnyav thiab me me zoo sib xws.
2. Qhov thib ob, Azvudine kho ob qho tib si cov tsos mob thiab cov tsos mob.
Ntawm qib cellular, Azvudine lub zog tiv thaiv kab mob tiag tiag tsis muaj zog li Remdesivir, plaub lossis tsib zaug phem dua li Remdesivir, tab sis cov txiaj ntsig kho mob zoo dua li Remdesivir, thiab nws tuaj yeem noj hauv qhov ncauj ntawm 5mg, Remdesivir txhaj yog 100mg.
Qhov no coj peb mus rau lo lus nug uas yuav tsum muaj qhov tseem ceeb ntawm kev ua si uas peb tsis nkag siab. Lo lus nug no yog qhov pib rau peb pib qhov project no. Azvudine tom qab tau pom tias yog RNA polymerase inhibitor. Txawm li cas los xij, qhov dav dav RNA polymerase inhibitor yog cov tshuaj nucleoside, uas yuav tsum muaj peb phosphorylation, thiab cov txheej txheem phosphorylation yog qhov nyuaj. Piv txwv li, Remdesivir ntxiv phosphoric acid rau nws, tab sis Azvudine tsis ntxiv phosphoric acid. Tom qab ntawd, peb pom tias azvudine tuaj yeem faib rau ntau yam kabmob hauv lub cev thiab ua tiav peb phosphorylation hauv thymus.
Lub caj pas thymus tseem ceeb heev. Thaum muaj hnub nyoog 15 xyoos, thymus yog qhov loj tshaj plaws, thiab tom qab muaj hnub nyoog 45 xyoos, thymus shrinks mus rau qhov loj me me. Yog li tom qab muaj hnub nyoog 45 xyoos, kev tiv thaiv ntawm cov neeg laus nruab nrab pib poob qis, yog li nws yuav mob, xws li qog. Cov yas tshiab kuj tseem ua rau cov neeg laus tuag ntau dua vim tias nws muaj T hlwb tsawg dua.
Cov lus teb peb pom yog: Azvudine ua tiav peb phosphorylations hauv thymus, tshem tawm cov kab mob hauv thymus, tiv thaiv lub cev tiv thaiv kab mob, thiab lub cev tiv thaiv kab mob kuj muaj cov tshuaj tua kab mob.
Yog li, kuv xav tias cov tshuaj no yog ob txoj kev kho mob. Thawj yog cov tshuaj tiv thaiv kab mob, thiab nws cov tshuaj tiv thaiv kab mob feem ntau yog tsom rau hauv thymus. Lub thymus yog ib qho amplifier uas tuaj yeem rhuav tshem cov kab mob thoob plaws hauv lub cev ntev npaum li T cells muaj peev xwm tsim cov haujlwm txaus. Qhov thib ob yog los tiv thaiv kev ua haujlwm ntawm tus kabmob tshiab RdRP.
(Lwm cov ntaub ntawv peb tau pom qhia tau hais tias tom qab azvudine nkag mus rau tib neeg lub cev, kev faib tawm kuj tseem tshwj xeeb, thiab kev faib tawm ntawm thymus yog qhov loj tshaj plaws. Azvudine nkag mus rau hauv lub cev thiab tsis nyob hauv cov ntshav rau lub sijhawm ntev. Ntau nws yuav decomposed rau hauv daim ntawv ntawm triphosphate thiab nkag mus rau hauv lub cell, uas yuav nyob twj ywm nyob rau hauv lub CD4 / CD8 hlwb, thiab ib nrab-lub neej nyob rau hauv lub cell yog hais txog 160 teev ntxiv).
Azvudine muaj cov haujlwm ntawm kev kho cov tsos mob thiab cov hauv paus hniav. Antiviral yog "cov tsos mob", thiab kev tiv thaiv thymus yog sib npaug rau "hauv paus".
Tau qhov twg los: eastmoney.com
Guanine, as cov khoom siv tseem ceeb ntawmAzvudine,peb muajmus sij hawm ntev kev koom tes nrog haib manufacturers thiabmuajpabied nws ntev. Zoo siab txais tos txhua tus phooj ywg uas xav tau kev sab laj.
