Dab tsi yog selpercatinib intermediates?
Selpercatinib intermediates xa mus rau cov tshuaj tseem ceeb precursors thiab cov khoom nruab nrab siv hauv kev sib txuas ntawm selpercatinib (LOXO292), ib qho kev xaiv RET kinase inhibitor. Selpercatinib feem ntau yog siv los kho cov qog nqaij hlav xws li tsis yog -mob qog nqaij hlav qog noj ntshav thiab medullary thyroid cancer harboring RET fusions lossis kev hloov pauv, thiab nws cov synthesis cia siab rau cov neeg nruab nrab rau cov qauv tsim.
Cov intermediates no feem ntau muaj cov yam ntxwv heterocyclic scaffolds zoo li pyrazolo [1,5-a] pyridine, nrog rau cov pab pawg ua haujlwm xws li bromine atoms, pawg methoxy, thiab cyano pawg. Lawv lub luag haujlwm tseem ceeb yog tsim cov tshuaj lub hauv paus pharmacophore, qhia cov txheej txheem tseem ceeb, thiab ua tiav cov kev xaiv ua haujlwm hloov pauv.
Raws li tus choj tseem ceeb txuas cov khoom siv tshuaj lom neeg thiab cov tshuaj kawg, lawv ncaj qha cuam tshuam rau kev ua tau zoo, khoom purity, thiab stereoselectivity ntawm txoj kev hluavtaws. Lawv yog ib qho tseem ceeb rau kev ua kom zoo, ua tau zoo, thiab kev nyab xeeb ntawm selpercatinib, thiab yog qhov tseem ceeb hauv R & D thiab kev lag luam tsim cov tshuaj tiv thaiv kab mob.
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![CAS: 1207836-10-9 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile]()
CAS: 1207836-10-9 6-bromo-4-methoxypyrazolo[1,5-a]pyridin...CAS Nr .: 1207836-10-9. MF C₉H₆BrN₃O. MW 252.07.
![CAS: 1207836-10-9 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile](/uploads/24095/small/cas-1207836-10-9a25d7.png?size=380x0)
Peb paub zoo-paub tias yog ib qho ntawm cov ua lag luam selpercatinib intermediates manufacturers thiab lwm tus neeg nyob hauv Suav teb. Peb lub Hoobkas muaj cov khoom zoo selpercatinib intermediates ua nyob rau hauv Suav teb nrog cov nqi sib tw. Txais tos tiv tauj peb rau kev pabcuam lag luam wholesale.
