Thaum xyoo 1980s, US Food and Drug Administration (FDA) tau tso cai ursodeoxycholic acid ua kev kho mob rau daim siab. Cov tshuaj patent tas sij hawm thiab tam sim no muaj nyob rau hauv ib tug generic.
Thaum Lub Kaum Ob Hlis 5, 2022, pab pawg tshawb fawb los ntawm University of Cambridge tau luam tawm ib daim ntawv hu ua "FXR inhibition tuaj yeem tiv thaiv los ntawm SARS-CoV-2 kab mob los ntawm kev txo qis ACE2" nyob rau hauv cov ntawv xov xwm thoob ntiaj teb sab saum toj Nature. Txoj kev tshawb nrhiav pom tias ursodeoxycholic acid, tshuaj mob siab uas tso tawm ACE2 receptors thiab kaw lub qhov rooj rau cov kab mob nkag mus rau hauv cov hlwb, tuaj yeem siv los tiv thaiv COVID-19 kab mob, thiab txij li cov tshuaj tiv thaiv lub hom phiaj ntawm lub cell ntau dua li tus kab mob. , nws tuaj yeem tiv thaiv cov kab mob tshiab yav tom ntej nrog rau lwm cov kab mob coronaviruses uas yuav tshwm sim.
Raws li cov pov thawj no, pab pawg tau zoo siab tias ursodeoxycholic acid muaj peev xwm los ua riam phom tseem ceeb hauv kev tawm tsam COVID-19.
Ursodeoxycholic acid nkag rau hauv kev ua lag luam tam sim no feem ntau yog hluavtaws, cov txheej txheem hluavtaws muaj xws li tshuaj synthesis thiab bioenzyme txoj kev. Tshuaj synthesis ntawm ursodeoxycholic acid yog ib qho nyuaj, yuav tsum tau ntau kauj ruam ntawm hydroxyl tiv thaiv thiab deprotection, uas ua rau tag nrho cov yield tsawg thiab tus nqi siab. Ursodeoxycholic acid (CDCA) raws li cov khoom siv raw yog npaj los ntawm ob-kauj ruam enzymatic txoj kev, uas muaj qhov zoo ntawm txoj kev luv luv thiab tus nqi qis, yog li nws yog siv ntau dua hauv kev tsim khoom. Enzymatic synthesis ntawm UDCA txoj kev:
