Nyob rau yav tav su ntawm Lub Kaum Hli 26th, 11th Medidata NEXT Tuam Tshoj Lub Rooj Sib Tham Txhua Xyoo 2022 Suzhihua Tshuaj Tshawb Fawb thiab Kev Txhim Kho sub-conference tau muaj nyob online. Medidata Tom ntej no Tuam Tshoj Lub Rooj Sab Laj Txhua Xyoo, nrog lub ntsiab lus ntawm "Brave to Think ahead, Create the Future", yog tuav los ntawm Medidata, lub koom haum ua lag luam tag nrho ntawm Dassault Systemes, Fabkis. Nws coj los ua ke thoob ntiaj teb cov kws tshaj lij bioscience innovators, sib pauv thiab sib tsoo cov tswv yim nrog kev pom, sib tham txog thaj tsam ntawm cov tshuaj digital, thiab siv lub mem tes ntawm txoj kev loj hlob ntawm cov tshuaj. Nws nthuav tawm ib qho kev tshwm sim loj rau kev sib pauv tswv yim, kev koom tes thiab kev loj hlob.
Ntawm lawv, Suzhihua Tshuaj Tshawb Fawb thiab Kev Txhim Kho Lub Rooj Sib Tham tshwj xeeb tau caw Dassault BIOVIA lub neej kev tshawb fawb kev daws teeb meem kws pab tswv yim Hua Peng, Beigen Kev Tshawb Fawb Kev Tshawb Fawb thiab Kev Txhim Kho Senior Director Gao Yang, Wuxi HitS Division Tus Thawj Coj Dr. Yin Jian, Beijing Zhuoya Medical Technology Co., LTD CEO Zhou Zhuang , lub ntsiab lus qhia tsom rau kev tshawb fawb txog tshuaj thiab kev tsim kho tshuab.
Kev tshawb fawb thiab kev tsim tshuaj digital ntse yog ib qho ntawm cov haujlwm tseem ceeb uas cov neeg ua haujlwm hauv kev lag luam tau mloog zoo, kom tsis txhob muaj kev ntxhov siab los ntawm kev tswj hwm kev tswj hwm, cov ntaub ntawv txheeb cais tsis raug thiab lwm yam teeb meem, txhawm rau ua tiav kev sim ua haujlwm ntse, kev ua haujlwm, kev tshawb fawb thiab kev txhim kho kev tswj hwm. , yog ib qho tseem ceeb txhais tau tias los txhim kho kev tshawb fawb thiab kev loj hlob muaj peev xwm ntawm kev lag luam tshuaj, ntxiv dag zog rau kev tsim khoom. Yuav siv cov kev txawj ntse digital li cas los pab txoj kev tshawb fawb tshuaj thiab kev tsim kho tshiab? Yuav ua li cas txhawm rau txhim kho kev ua haujlwm ntawm kws tshuaj R & D los ntawm Informatization?
Raws li thawj tus qhua hais lus, Mr. Hua Peng, Tus Kws Pab Tswv Yim ntawm BIOVIA life Science Solutions of Dassault Systemes, tau qhib lub rooj sib tham nrog tsab ntawv ceeb toom hu ua "ELN System Pab Txhawb Kev Hloov Kho ntawm Digital Intelligence hauv Tshuaj R & D Laboratories". Nws thawj zaug txheeb xyuas tsib qhov kev sib tw ntau tshaj plaws hauv R & D LABS:
● Nrhiav cov ntaub ntawv: yuav ua li cas nrhiav cov ntaub ntawv thiab cov ntaub ntawv sai thiab raug thaum xav tau.
● Npaj thiab khaws cov ntaub ntawv: yuav ua li cas faib thiab khaws cov ntaub ntawv hauv txoj hauv kev tsim nyog kom yooj yim rau kev nkag, txheej txheem thiab tshuaj xyuas.
● Sib faib cov ntaub ntawv: Sib qhia cov ntaub ntawv nrog lwm tus neeg lossis lwm lub koom haum feem ntau siv sijhawm ntau thiab siv zog.
● Siv ntau lub tshuab: ntau lub tshuab thiab cov chaw khaws ntaub ntawv nce nqi kho thiab txo cov ntaub ntawv nkag mus tau zoo.
● Kev tswj cov ntaub ntawv ntau: Qhov kev tshawb fawb ntau zuj zus tau ua rau muaj qhov ntim ntawm cov ntaub ntawv tshawb fawb sai, uas yuav tsum tau muaj txiaj ntsig zoo dua los daws nws.
Hauv qhov no, nws ntseeg tias:
Hloov cov kev tswj hwm ib txwm siv ntawm chav kuaj: piv txwv li, BIOVIA Workbook ELN system yog siv los txhim kho kev tswj xyuas chav kuaj hauv txhua theem los ntawm kev siv cov qauv kev sim, kev sim cov lus nug, cov ntaub ntawv ua, kev sim qhia, tshawb xyuas txoj kev thiab lwm yam haujlwm.
Kev tsim kho ntawm R & D lub chaw soj nstuam ecosystem: Los ntawm kev tsim kom muaj kev sib koom ua ke nrog rau kev tswj cov ntaub ntawv, kev tswj xyuas cov cuab yeej, biomacromolecule thiab cov tsev qiv ntawv sib xyaw, kev tswj xyuas haujlwm thiab lwm yam qauv, nrog rau kev koom ua ke nrog lwm yam ntawm cov txheej txheem thib peb thiab cov kev pab cuam, kom ua tiav kev sim ua haujlwm zoo cov ntaub ntawv sib txuas.
Raws li Hua Peng, BIOVIA Workbook yuav pab tshuaj kho tshiab thiab ua kom cov tshuaj tshiab
Tom qab ntawd, Gao Yang, tus thawj coj loj ntawm kev tshawb fawb thiab kev loj hlob ntawm Beigene, tau ua ib daim ntawv tshaj tawm hu ua "Ua raws li ELN Assisted drug process research and Development". Gao Yang tau taw qhia tias hauv cov txheej txheem tshuaj tshawb fawb thiab kev tsim kho, kev soj ntsuam kev pheej hmoo zoo (QRA) ntawm API txheej txheem yog ib feem tseem ceeb ntawm cov khoom lag luam daim ntawv thov cov ntaub ntawv, uas yog ib qho tseem ceeb heev rau cov khoom lag luam. Hauv particular, impurity nqa cov kev tshawb fawb (F&P) muab cov ntaub ntawv tseem ceeb los ua kom pom cov txheej txheem kev tshem tawm impurity, yog li cov ntaub ntawv kev ncaj ncees thiab kev ntseeg siab yuav tsum tau. "Cov qauv kev sim nyuaj coj cov teeb meem loj rau cov ntaub ntawv ncaj ncees". Yog li, kev sim tsim raws li ELN yog qhov tseem ceeb tshwj xeeb. Raws li cov ntaub ntawv sau thiab ua cov platform, ELN tuaj yeem txo tib neeg kev ua yuam kev thiab txhim kho kev ua haujlwm. Txoj kev tshawb xyuas thiab kev kos npe hluav taws xob ua haujlwm ntawm ELN kuj ua kom cov ntaub ntawv muaj tseeb thiab kev ntseeg tau.
Dr. Jian Yin, Tus Thawj Coj ntawm Wuxi Apptec HitS, tau nthuav tawm tsab ntawv ceeb toom "Tshiab Txoj Haujlwm rau CADD thiab Chemoinformatics hauv Biomedicine". Dr. Yin taw qhia tias nrog kev tawg ntawm txoj kev kawm tob thiab kev suav huab hauv xyoo tas los no, muaj ntau chav rau CADD ib txwm ua haujlwm. Tsis tas li ntawd, qee qhov kev siv thev naus laus zis ntawm kev tshawb nrhiav tshuaj, xws li DNA coding compound tsev qiv ntawv thev naus laus zis, tau lees paub los ntawm ntau tus neeg siv tshuaj tshawb pom tshiab, thiab kuj tau tsim cov ntaub ntawv loj. Yog li ntawd, yuav ua li cas ua kom cov ntaub ntawv no ua lub luag haujlwm zoo dua tau dhau los ua lub ntsiab lus tseem ceeb rau CADD thiab chemoinformatics ua ke nrog kev kawm tob tob los ua lub luag haujlwm ntawm biomedicine.
Hauv kev txhim kho qee cov qauv tshiab thiab cov tshuaj kub, xws li covalent me me molecule tshuaj, tshuaj tiv thaiv kab mob, PROTAC, PPI, thiab lwm yam, kev sib xyaw ntawm CADD thiab AlphaFold kuj tuaj yeem ua lub luag haujlwm ua khawv koob.
Thaum kawg, Zhou Zhuang, CEO ntawm Beijing Zhuoya Medical Technology Co., LTD., tau nthuav tawm tsab ntawv tshaj tawm "BIOVIA Molecular Simulation thiab Data science software Enabling a New Model of Drug Development". Kev tshawb fawb tshuaj tshiab thiab kev tsim kho tshiab tau lees paub thoob ntiaj teb raws li qhov tseem ceeb ntawm "peb siab thiab ib qho ntev", uas yog "siab thev naus laus zis, kev nqis peev siab, kev pheej hmoo siab, lub voj voog ntev". Nyob rau hauv cov ntsiab lus no, Zhou ntseeg hais tias kev ua qauv thiab simulation cov tswv yim muab kev muaj peev xwm ntawm atomic-theem kev sib cuam tshuam uas txhawb kev tshawb nrhiav tshuaj, ua rau cov kws tshawb fawb hauv kev lag luam hauv lub neej los sim "lub tswv yim-rau-qhov tseeb" muaj peev xwm nrog kev pheej hmoo tsawg thiab tus nqi qis. Nws tau hais tias Dassault Systemes BIOVIA muab kev lag luam kev tshawb fawb txog lub neej nrog cov cuab yeej tshawb fawb molecular thiab simulation kev tshawb fawb, thiab tuaj yeem sib txuas cov ntaub ntawv tshawb fawb software kom ua tiav txhua yam ntawm cov ntaub ntawv nkag mus thiab sib sau ua ke rau cov ntaub ntawv nyuaj, qauv thiab qhia. Lub automation ntawm cov txheej txheem no tso cai rau cov kws tshawb fawb los ua qhov feem ntau ntawm lawv cov ntaub ntawv. Pab cov kws tshawb fawb tsim cov khoom lag luam zoo dua, muaj kev nyab xeeb dua, thiab muaj txiaj ntsig zoo dua los txhim kho cov txiaj ntsig ntawm tus neeg mob.
Raws li lub ntiaj teb kev lag luam kws tshuaj hloov cov txheej txheem sai dua thiab nrawm dua, cov thev naus laus zis tshiab tau nthuav tawm tas li, thiab nws daim ntawv thov tau dhau los ua cov cuab yeej ntse hauv kev tshawb fawb thiab kev tsim cov tshuaj ntse digital. BIOVIA yuav txuas ntxiv tsom mus rau kev tshawb nrhiav tshuaj thiab coj cov kev paub dhau los thiab cov kev daws teeb meem digital rau lub ntiaj teb kev tshawb fawb txog kev ua neej nyob.
