Hauv txoj kev tshawb fawb tshiab, cov kws tshawb fawb los ntawm Case Western Reserve University thiab Metro Health Tsev Kho Mob hauv Tebchaws Meskas tau ua tiav hauv kev nthuav tawm qhov tsis meej ntawm cov protein receptor --- EphA2 --- uas ob leeg inhibits qog nqaij hlav thiab txhawb nws txoj kev loj hlob thiab kev sib kis. . Cov kev tshawb pom qhia tias yuav ua li cas thiab vim li cas EphA2 receptor plays lub luag haujlwm ntawm kev sib ntaus sib tua thiab txhawb nqa nws. Cov kev tshawb pom tau luam tawm nyob rau lub Kaum Ob Hlis 1, 2023 qhov teeb meem ntawm Kev Tshawb Fawb nyob rau hauv lub npe "Lub sij hawm daws teeb meem nyob-cell spectroscopy qhia EphA2 multimeric los ua ke". Txoj kev tshawb no tshiab tau coj los ntawm Bingcheng Wang, tus xibfwb ntawm Case Western Reserve University School of Medicine.
Kev tshawb pom zoo li no ua rau nws tuaj yeem kho mob qog noj ntshav, "Wang hais. Raws li tus kws tshawb fawb mob qog noj ntshav, tsis muaj kev ua tiav ntau dua ... Tab sis qhov khoom plig zoo tshaj plaws yog paub tias kev nce qib uas peb tab tom ua yuav cuam tshuam rau peb tus kheej cov neeg mob thiab lwm tus. thoob ntiaj teb."
Ib tug pioneer hauv EphA2 kev tshawb fawb rau 25 xyoo, Wang tau ua zoo strides nyob rau hauv lub tshav pob, nrhiav tau lub receptor lub peev xwm los inhibit tus cwj pwm ntawm malignant qog nyob rau hauv 2000 thiab nws lub luag hauj lwm nyob rau hauv txhawb carcinogenesis tom qab hloov kho nrog qog nqaij hlav proteins nyob rau hauv 2009. Modified EphA2 ua rau Nws hais tias cov qog nqaij hlav cancer kom loj hlob, tswj cov qia cell, thiab metastasize rau lwm qhov hauv lub cev, nws hais.
Tam sim no, tom qab xyoo ntawm kev tshawb fawb, cov kws sau ntawv no tau txheeb xyuas seb EphA2 ua haujlwm li cas rau ob lub luag haujlwm no hauv kev mob qog noj ntshav. Siv lub tshuab txiav-ntug spectroscopy platform (PIE-FCCS) los soj ntsuam cov hlwb nyob hauv molecularly, lawv pom tias EphA2 nws pib sib sau ua ke los ntawm ob qho kev sib cuam tshuam ntawm EphA2 cov molecules nyob sib ze, "ua" lawv ua ke. Ib qho ntawm cov kev sib cuam tshuam no ua rau muaj kev cuam tshuam rau kev mob qog noj ntshav, thaum lwm qhov ua rau lawv cov teebmeem mob qog noj ntshav.
Duab los ntawm Science, 2023, doi: 10.1126/science.adg5314.
Xiaojun Shi, tus kws sau ntawv ntawm daim ntawv thiab tus kws tshawb fawb postdoctoral ntawm Case Western Reserve University, ua ke nrog kev paub txog kev yees duab molecular nrog kev sim kev txawj ntse hauv kev mob qog noj ntshav kom ua tau qhov kev tshawb pom. John Chae, tus thawj saib xyuas haujlwm laus rau kev kho mob ntawm Case Western Reserve University School of Medicine, tau hais txog qhov tseem ceeb ntawm qhov kev tshawb pom.
Qhov no yog hom kev tshawb fawb yooj yim uas txoj kev cawm neeg txoj sia nyob ntawm, "Chae tau hais tias.
