Non-small cell lung cancer (NSCLC) yog ib yam kab mob loj uas ua rau tib neeg noj qab haus huv, thiab qhov xwm txheej thiab kev tuag tau nce zuj zus txhua xyoo thoob ntiaj teb. 85 feem pua ntawm NSCLC pathological kev faib tawm yog nyob rau hauv lub ntsws adenocarcinoma. Qhov tshwm sim ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob coj teeb pom kev rau NSCLC txoj kev kho, thiab cov tshuaj tiv thaiv kab mob Pembrolizumab tsom PD-1 / PD-L1 yog thawj kab tshuaj pom zoo rau kev kho mob siab thiab metastatic NSCLC. Txawm hais tias cov neeg ua haujlwm no tau pom tias muaj txiaj ntsig zoo dua hauv kev kho mob metastatic lossis hauv zos nce siab NSCLC, tsuas yog 15 feem pua - 30 feem pua ntawm cov neeg mob uas muaj NSCLC siab heev tuaj yeem ua tiav kev tshem tawm thiab muaj sia nyob mus ntev los ntawm kev siv tshuaj tiv thaiv kab mob, nrog rau cov qog nqaij hlav tiv thaiv kab mob microenvironment yog nws qhov laj thawj tseem ceeb. . Yog li ntawd, nws yog ib qho tseem ceeb heev los tshawb nrhiav cov neeg tsav tsheb ntawm inhibitory TIME tsim los txhim kho kev ua tau zoo ntawm kev tiv thaiv kab mob hauv NSCLC.
Cov tshuaj hormones endocrine muaj feem cuam tshuam nrog kev tiv thaiv qog nqaij hlav. Hauv qee cov qog nqaij hlav endocrine (xws li mob qog noj ntshav mis, thiab lwm yam), kev koom tes ntawm cov tshuaj hormones hauv cov qog tiv thaiv kab mob tau raug tshawb fawb tob, thiab kev kho endocrine tau dhau los ua ib qho tseem ceeb rau kev kho cov qog no. NSCLC tsis yog nruj me ntsis rau cov qog endocrine, tab sis ntau thiab ntau cov kev tshawb fawb qhia tau hais tias kev loj hlob thiab metastasis ntawm cov qog nqaij hlav cancer hauv lub ntsws yog tswj los ntawm ntau yam tshuaj hormones, nyob rau hauv daim nyias nyias muaj ntau cov tshuaj hormones receptors, txawm li cas los xij, cov zej zog kho mob yuav ua li cas cov tshuaj hormones endocrine koom nrog. nyob rau hauv NSCLC qog lub cev tiv thaiv kab mob microenvironment kev cai, yuav ua li cas cuam tshuam rau NSCLC kev tiv thaiv kab mob.
Tsis ntev los no, pab pawg tshawb fawb ntawm Xib Fwb Yin Wu los ntawm Lub Tsev Kawm Ntawv ntawm Kev Tshawb Fawb Txog Lub Neej ntawm Nanjing University tau luam tawm hauv Science subjournal Science Advances txoj cai: Na, Thiab K-ATPase 1 koom tes nrog nws cov ligand endogenous rau reprogram tiv thaiv kab mob microenvironment ntawm lub ntsws carcinoma thiab txhawb kev tiv thaiv kab mob. ntawv tshawb fawb.
Xibfwb Yin Wu pawg tshawb fawb tau kawm txog kev ua haujlwm lom neeg tshiab ntawm cov tshuaj endocrine —— endogenous Endogenous Ouabain (EO) uas tsim los ntawm cov qog adrenal. Los ntawm ntau qhov kev kuaj mob thiab kev lees paub txog kev ua haujlwm lom neeg, lawv pom tias EO yog cov tshuaj endocrine tshiab uas tuaj yeem txhawb nqa kev tiv thaiv kab mob microenvironment ntawm NSCLC.
Waabain yog ib hom tshuaj riam phom uas tsim los ntawm cov nroj tsuag siab dua los tiv thaiv kab invasion, tab sis qhov txawv txav ntawm EO tau pom nyob rau hauv cov ntshav ntawm cov neeg mob uas tsis yog me me ntawm lub ntsws ntsws adenocarcinoma, thiab qhov nyiaj ntawm EO qhia yog ze ze rau cov qog metastasis thiab cov neeg mob prognosis. . Kev tshawb fawb ntxiv pom tias nyob rau hauv kev loj hlob ntawm lub ntsws adenocarcinoma, lub qog adrenal tuaj yeem "hijacked" los ntawm cov qog kom tso tawm EO, thiab EO nyob rau hauv microenvironment ntawm lub ntsws adenocarcinoma "txawj" siv sodium thiab potassium ATP enzyme receptor "desensitization" kom raug tswj PD. -L1 qhia thiab txhawb cov qog tiv thaiv kab mob khiav tawm. Qhov tshiab ntawm cov txiaj ntsig tau raug ntsuas los ntawm cov kws tshaj lij thoob ntiaj teb.
Txoj kev tshawb no nthuav dav cov kev ua haujlwm lom neeg tshiab ntawm EO, thiab muab lub hauv paus theoretical rau kev tshawb pom cov txheej txheem tshiab ntawm cov qog tiv thaiv kab mob tawm thiab txhim kho cov nyhuv ntawm kev tiv thaiv kab mob hauv lub ntsws adenocarcinoma.
