Messenger RNA (mRNA) lipid nanoparticle (LNP) cov tshuaj tiv thaiv tam sim no yog ib qho kev txhaj tshuaj tiv thaiv zoo, thiab txawm tias tam sim no nws tsim nyog rau cov kab mob kis, muaj cov ntaub ntawv tsawg heev ntawm kev ua haujlwm ntawm lub platform tiv thaiv kab mob. Hauv kev tshawb fawb luam tawm hauv Ib koob tshuaj F1-raws li mRNA-LNP tshuaj tiv thaiv muab kev tiv thaiv kab mob plague kab mob Science Advances, cov kws tshawb fawb los ntawm Tel Aviv University thiab lwm tus tau tsim thawj cov tshuaj tiv thaiv mRNA uas tuaj yeem yog 100. feem pua zoo tiv thaiv kab mob uas tua tib neeg.
Los ntawm kev kawm cov qauv tsiaj, cov kws tshawb fawb pom tias txhua tus tsiaj kho tau tiv thaiv kab mob (Yersinia pestis), cov cuab yeej tshiab uas tuaj yeem pab tsim cov tshuaj tiv thaiv kab mob sai sai, suav nrog cov kab mob tshwm sim los ntawm cov kab mob tiv thaiv kab mob. Tus kws tshawb nrhiav Edo Kon tau piav qhia tias, txog tam sim no, cov tshuaj tiv thaiv mRNA (xws li cov tshuaj tiv thaiv mRNA tiv thaiv COVID-19) yog cov khoom siv dag zog tiv thaiv kab mob, Tab sis nws tsis muaj kev cuam tshuam rau cov kab mob; Tab sis qhov zoo tshaj plaws ntawm cov tshuaj tiv thaiv zoo li no, dhau ntawm lawv cov txiaj ntsig, Yog tias nws tuaj yeem tsim tau sai heev, Thaum cov kab mob caj ces xws li SARS-CoV-2 cov kab mob tau tshaj tawm, Nws siv cov kws tshawb fawb tsuas yog 63 hnub los pib thawj zaug. kev sim tshuaj; tseem, txog rau tam sim no, Cov neeg tshawb xyuas ntseeg tias, Ntawm mRNA cov tshuaj tiv thaiv kab mob tiv thaiv kab mob tsis tuaj yeem siv tau, Hauv txoj kev tshawb no, Cov kws tshawb fawb tau tsim 100 feem pua mRNA tshuaj tiv thaiv kab mob tuag taus.
Vim hais tias tus kab mob no ua rau cov proteins nyob rau hauv peb lub hlwb, thiab cov proteins uas txhais los ntawm cov kab mob genetic kab mob zoo ib yam li cov mRNA txhais los ntawm kev kuaj; Txawm li cas los xij, cov kab mob tuaj yeem yog ib zaj dab neeg sib txawv kiag li, lawv tsis xav kom tus tswv tsev lub hlwb los tsim lawv cov proteins, thiab vim tias cov txheej txheem evolution ntawm tib neeg thiab cov kab mob tsis zoo ib yam, cov protein uas tsim los ntawm cov kab mob sib txawv ntawm cov proteins uas tsim los ntawm tib neeg. cov hlwb, txawm tias nyob ntawm tib lub genetic sequence. Cov kws tshawb fawb sim ua kom cov kab mob sib xyaw ua ke hauv tib neeg lub hlwb, tab sis raug rau cov proteins no tuaj yeem ua rau lub cev tsis muaj cov tshuaj tiv thaiv kab mob thiab feem ntau tsis muaj kev tiv thaiv kab mob, tej zaum vim tias, txawm hais tias cov kab mob protein thiab qhov tseem ceeb ntawm tib cov protein synthesized hauv chav kuaj, thiab yog. raws li tib "kev qhia kev tsim khoom", tab sis cov protein tsim tawm hauv tib neeg lub hlwb hauv kev tso tawm los ntawm tib neeg lub hlwb muaj kev hloov pauv loj, xws li yuav nce qib ntawm cov piam thaj molecules, thiab lwm yam.
Yuav kom daws tau qhov teeb meem no, cov kws tshawb fawb tau tsim cov txheej txheem ntawm secreted bacterial protein, tab sis kuj bypass lub classic secretion txoj kev, txoj kev no yog feem ntau yuav muaj teeb meem nyob rau hauv daim ntawv thov no, qhov tshwm sim yog ib qho tseem ceeb tiv thaiv kab mob, lub cev tiv thaiv kab mob yuav ua tau. Cov tshuaj tiv thaiv kab mob raws li cov kab mob immunogenic cov kab mob, txhawm rau txhim kho kev ruaj ntseg ntawm cov kab mob cov kab mob thiab xyuas kom meej tias nws yuav tsis tawg sai sai hauv lub cev, cov kws tshawb fawb siv ib feem ntawm tib neeg cov protein ntxiv rau nws qhov kev txhawb zog, los ntawm kev sib koom ua ke ob txoj kev sib tw, cov kws tshawb fawb tuaj yeem tau txais. kev tiv thaiv kab mob. Xib fwb Peer tau hais tias, muaj ntau cov kab mob pathogenic peb tsis muaj tshuaj tiv thaiv, ntxiv rau, vim tias kev siv tshuaj tua kab mob ntau dhau, ntau cov kab mob muaj qee qhov kev zam rau cov tshuaj tua kab mob, yog li ntawd, cov kab mob resistant tau ua rau muaj kev hem thawj rau tib neeg ntiaj teb kev noj qab haus huv, yog li tsim ib qho tshuaj tiv thaiv tshiab tuaj yeem muab tau qee lub hauv paus los txhim kho tib neeg kev noj qab haus huv.
Hauv txoj kev tshawb no, cov kws tshawb fawb tau sim cov tshuaj tiv thaiv mRNA tshiab hauv kev kho cov kab mob tuag taus. Tsis pub dhau ib lub lis piam tag nrho cov tsiaj tsis tau txhaj tshuaj tau tuag thiab cov tsiaj uas tau txhaj tshuaj tshiab tau muaj sia nyob zoo; Tsis tas li ntawd, nyob rau hauv ib qho ntawm cov tswv yim tshuaj tiv thaiv, ib koob tshuaj tiv thaiv tau muab kev tiv thaiv tag nrho tom qab ob lub lis piam, nrog lub peev xwm ntawm ib koob nkaus xwb los muab kev tiv thaiv tag nrho rau yav tom ntej uas kis kab mob thiab kis tau sai. Nws yog ib qho tsim nyog yuav tsum nco ntsoov tias cov tshuaj tiv thaiv COVID-19 tau tsim sai heev vim nws vam khom ntau xyoo ntawm kev tshawb fawb txog cov tshuaj tiv thaiv mRNA uas muaj cov kab mob zoo sib xws. Yog tias peb ntsib tus kab mob kis thoob plaws tag kis, peb txoj kev tshawb fawb yuav muab txoj hauv kev tshiab rau kev txhim kho sai ntawm cov tshuaj tiv thaiv mRNA muaj kev nyab xeeb thiab zoo.
Hauv kev xaus, cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tau tias cov tshuaj tiv thaiv mRNA-LNP tshiab no tuaj yeem tsim cov tshuaj tiv thaiv kab mob humoral thiab cellular tiv thaiv kab mob hauv C57BL / 6 nas thiab muab kev tiv thaiv sai thiab dav tiv thaiv Y. pestis tom qab ib koob tshuaj ib zaug, thiab cov txiaj ntsig tuaj yeem qhib qhov tshiab. txoj hauv kev rau kev txhim kho cov tshuaj tiv thaiv kab mob tiv thaiv kab mob sai sai.
