Spermidine yog ib yam khoom muaj nyob hauv lub cev nws tus kheej. Thaum peb muaj hnub nyoog, qib ntawm spermidine hauv lub cev txo qis. Kev ntxiv cov spermidine pab lub cev txuas ntxiv mus ntxuav nws tus kheej, thiab cov khoom qub thiab cov cellular ntau dhau thiab cov neeg ua phem phem xws li cov kab mob tau tawg thiab rov ua dua tshiab. Thaum kawg, nws tuaj yeem txhim kho, hloov kho thiab ntxuav cov hlwb los ntawm cov hauv paus hniav ntawm cov hlwb, kom tsis txhob muaj ntau yam kab mob thiab cov kab mob metabolic tshwm sim los ntawm kev puas tsuaj ntawm tes.
autophagy yog ib qho ntawm cov txheej txheem uas cov hlwb tshem tawm cov kab mob thiab cov protein. Nws yog ubiquitous nyob rau hauv cov kab mob eukaryotic thiab plays lub luag haujlwm tseem ceeb hauv kev tswj cov metabolism hauv cov hlwb.
Lo lus "autophagy" los ntawm Greek thiab txhais tau tias "noj tus kheej." Yooj yim muab tso, muaj cov denatured lossis puas hlwb hauv lub cev uas tsis ua rau lub cev, tab sis kuj tseem tuaj yeem tsim cov co toxins uas ua rau lub cev tsis zoo hauv peb lub cev. Autophagy yog los kho dua tshiab, kho thiab rov tsim cov hlwb degenerated los yog puas hauv lub cev, thiaj li ua tiav cov cell rov siv dua thiab rov siv dua, uas yog qhov tseem ceeb rau tib neeg kev noj qab haus huv.
Yoshinori Ohsumi, tus kws tshawb fawb Nyij Pooj uas yeej qhov khoom plig Nobel hauv physiology lossis tshuaj, thawj zaug tshawb pom lub tshuab ntawm autophagy hauv 2016 thiab txheeb xyuas 15 cov noob tseem ceeb koom nrog hauv autophagy.
Kev tshawb fawb hauv cov ntawv xov xwm saum toj kawg nkaus xws li Kev Tshawb Fawb tau pom tias spermidine muaj ntau yam kev tswj hwm lub cev, suav nrog autophagy, tiv thaiv kab mob, antioxidant, tiv thaiv plawv thiab neuroprotection, thiab lwm yam, thiab ntau cov txheej txheem physiological tswj los ntawm spermidine feem ntau cuam tshuam nrog induction ntawm autophagy los ntawm spermidine. Spermidine tswj qhov sib npaug ntawm cov cell txuas ntxiv los ntawm kev ua kom 15 hom autophagy yam hauv lub cev.
