Cov ntsiab lus
Targeted therapy yog ib qho tseem ceeb hauv kev kho mob qog noj ntshav. Piv nrog rau cov tshuaj cytotoxic ib txwm siv, cov kev kho mob tsom tau muaj txiaj ntsig zoo dua thiab ua kom ntev dua. Antibody coupled tshuaj (ADC) hauv kev kho mob yog ib qho kev tshawb fawb kub hauv kev tiv thaiv qog nqaij hlav hauv xyoo tas los. Tam sim no, 15 ADC tshuaj tau pom zoo rau kev lag luam hauv ntiaj teb, thiab ntau dua 70 ADC cov tshuaj hauv Suav teb yog nyob rau theem kev tshawb fawb thiab kev loj hlob sib txawv. Tsis tas li ntawd, ntau hom tshuaj conjugated tau tsim tas li, suav nrog cov tshuaj peptide conjugated (PDC), kab mob xws li tshuaj conjugates (VDC), antibody fragment conjugated drug (FDC), antibody immunostimulatory conjugates (ISAC), antibody biopolymer conjugates (ABC) , lwm.
Ntxiv rau ADC, feem ntau ntawm lwm cov tshuaj sib txuas tshiab yog nyob rau theem pib, thiab PDC kuj tau tsim. Nws yuav dhau los ua qhov chaw kub kub zoo li ADC yav tom ntej.
Taw qhia rau PDC tshuaj
Muaj peb yam khoom ntawm peptide ua ke tshuaj PDC: tsom peptide, tshuaj cytotoxic (cov tshuaj me me) thiab txuas. Raws li lub hom phiaj xa cov tshuaj xa tuaj, lub hom phiaj peptides yog covalently txuas nrog cov tshuaj lom tshuaj molecules los txhim kho cov hom phiaj tshuaj.
Cov qauv ntawm PDC zoo ib yam li ADC, tab sis qhov sib txawv yog tias lub hom phiaj ntawm PDC hloov los ntawm monoclonal antibody mus rau polypeptide. Lub tshuab ntawm PDC kuj zoo ib yam li ADC. Nws covalently txuas lub hom phiaj peptides thiab cytotoxins los ntawm cov kab txuas decomposable hauv cov hlwb, ua kom raug lub hom phiaj tshwj xeeb ntawm cov qog hlwb, thiab tswj tau tso tawm cytotoxins los tua cov qog hlwb.
PDC muab cov txiaj ntsig zoo ntawm peptides thiab muaj cov txiaj ntsig hauv qab no piv nrog ADC tshuaj:① me me molecular hnyav thiab muaj zog qog nkag;② Piv nrog rau cov txheej txheem complex ntawm antibody ntau lawm, nws yog yooj yim rau synthesize thiab purify, thiab cov nqi ntau lawm yog tsawg;③ Lub immunogenicity qis dua, thiab nws tsis yooj yim rau kev tiv thaiv kev ntxhov siab;④ Nws tuaj yeem raug tshem tawm sai sai los ntawm lub raum thiab txo qis toxicity rau cov pob txha pob txha thiab daim siab.
Vim nws muaj ntau yam zoo, PDC xav tias yuav dhau los ua ib tiam tshiab ntawm cov tshuaj tiv thaiv kab mob tom qab cov tshuaj me me, cov tshuaj tiv thaiv monoclonal thiab ADC tshuaj.