Txawm tias killer T cells (tshuaj tiv thaiv kab mob tshwj xeeb) uas ua haujlwm nyob ib ncig ntawm lub moos los nrhiav thiab rhuav tshem cov qog nqaij hlav cancer tuaj yeem ua rau qaug zog, thiab yog tias cov kws tshawb fawb tuaj yeem nkag siab tias vim li cas cov neeg tua neeg T hlwb ua rau qaug zog, lawv tuaj yeem tsim cov kab mob qog noj ntshav ntau dua. Hauv kev tshawb fawb tsis ntev los no tau luam tawm nyob rau hauv phau ntawv xov xwm thoob ntiaj teb Nature, lub npe "Beta-1 Adrenergic Receptor txuas cov paj hlwb rau T cell qaug zog," cov kws tshawb fawb los ntawm Salk Institute thiab lwm lub koom haum tau pom tias T hlwb tuaj yeem ua rau mob qog noj ntshav ntau dua. Nyob rau hauv txoj kev tshawb no hu ua "Beta-1 Adrenergic Receptor txuas cov hlab ntsha ntawm cov hlab ntsha mus rau T cell qaug zog", cov kws tshawb fawb los ntawm Salk lub koom haum thiab lwm lub koom haum tau pom muaj kev koom tes ntawm T cell qaug zog thiab lub cev lub siab xav teb ("sib ntaus-los- davhlau") los ntawm kev tshuaj xyuas ntau hom mob qog noj ntshav hauv nas thiab tib neeg cov ntaub so ntswg kuaj. kab mob los tswj cov ntshav siab thiab lub plawv dhia), yog li tsim cov tshuaj tua kab mob T hlwb uas tuaj yeem tua cov qog.
Hauv tsab xov xwm, cov kws tshawb fawb tau tsim cov kev sib txuas tshiab ntawm cov lus teb rau kev ntxhov siab thiab yuav ua li cas lub cev tiv thaiv kab mob ua rau mob qog noj ntshav, ntxiv rau qhov ua kom pom tias kev sib xyaw beta blockers nrog cov tshuaj tiv thaiv kab mob tam sim no tuaj yeem txhim kho kev kho mob qog noj ntshav los ntawm kev txhawb nqa kev ua haujlwm ntawm killer T hlwb. Tsis muaj qhov tsis ntseeg tias kev tiv thaiv kab mob tau hloov kho kev kho mob rau cov neeg mob qog noj ntshav, tab sis tseem muaj ntau tus neeg mob uas kho tsis zoo, thiab kev tshawb pom tias peb lub paj hlwb tuaj yeem cuam tshuam kev ua haujlwm ntawm cov qog nqaij hlav qog noj ntshav tuaj yeem qhib tag nrho txoj hauv kev tshiab rau kev xav. hais txog yuav ua li cas rov qab ua haujlwm ntawm T-hlwb hauv cov qog," tus kws tshawb fawb xibfwb Susan Kaech tau hais. Txawm li cas los xij, cov kws tshawb fawb tsis paub yuav ua li cas lub cev cov hlab ntsha tswj lub cev tiv thaiv kab mob los yog mob qog noj ntshav.
Hauv txoj kev tshawb no, cov kws tshawb fawb tau tsom mus rau cov paj hlwb uas muaj kev sib haum xeeb uas ua rau lub cev lub cev thiab tsim cov tshuaj hormone norepinephrine, cov tshuaj hormones kev ntxhov siab, thiab tom qab ntawd txheeb xyuas thaum twg thiab seb cov neeg tua neeg T-hlwb raug cuam tshuam li cas los ntawm cov hlab ntsha siab siv ntau hom kev mob qog noj ntshav. thiab kab mob nyob rau hauv cov ntaub so ntswg kuaj los ntawm nas thiab tib neeg. Nws tau pom tias cov paj hlwb ua rau muaj cov norepinephrine, uas khi rau cov neeg tua neeg T hlwb los ntawm kev siv cov receptor hu ua ADRB1, thiab cov neeg tua neeg uas tsis muaj zog T hlwb nthuav tawm ntau ADRB1 receptors tshaj lawv cov kev ua haujlwm, cia cov T hlwb mloog cov norepinephrine tso tawm los ntawm cov hlab ntsha. .
Txo kev ntxhov siab ntawm T hlwb tuaj yeem ua rau kev kho mob zoo dua rau cov neeg mob qog noj ntshav.
Duab los ntawm: Xwm (2023). DOI: 10.1038/s 41586-023-06568-6
Txhawm rau kuaj seb puas muaj cov kab mob tua neeg tua neeg tuaj yeem tiv thaiv tau, cov kws tshawb fawb tau sim ob txoj hauv kev los thaiv kev cuam tshuam ntawm norepinephrine nrog ADRB1, los ntawm kev tshem tawm ADRB1 tag nrho lossis los ntawm kev siv beta blocker los cuam tshuam ADRB1 txoj haujlwm, uas nyob rau hauv lem yuav ua tau ntau functionality. killer T hlwb uas yuav zoo dua ntawm kev rhuav tshem cov qog nqaij hlav cancer. Cov kws tshawb fawb tau pom tias cov T-cells uas tsis tau "mloog" cov hlab ntsha los ntawm qhov deb, tab sis sib sau ua ke nyob ib puag ncig lawv hauv cov ntaub so ntswg, thiab xav tsis thoob, ADRB1 receptor muab T-cells nrog cov lus qhia tseem ceeb los mus rau thaj tsam ntawm cov hlab ntsha, uas nyob rau hauv tig inhibits lawv txoj haujlwm thiab ua rau lawv hnyav dua ntawm kev tawm tsam mob qog noj ntshav. Raws li cov kws tshawb fawb, qog innervation yog ib qho chaw tsis muaj kev tshawb fawb ntawm cov qog qog nqaij hlav, thiab kev tshawb fawb tam sim no tau pom tias cov hlab ntsha txhawb cov txheej txheem ntawm T-cell depletion hauv cov qog, thiab lub sijhawm dhau los, T hlwb kuj ua rau qaug zog thiab tsis muaj zog hauv kev sib ntaus sib tua. qog nqaij hlav; Yog tias cov kws tshawb fawb tuaj yeem nthuav tawm cov ntsiab lus tom qab cov hlab ntsha tawg ntawm lub cev tiv thaiv kab mob rau cov qog nqaij hlav, thiab T cell depleted li cas lawv txav mus rau cov paj hlwb, tej zaum lawv yuav pib kho cov txheej txheem no.
Cov kws tshawb fawb vam tias yuav nthuav dav lawv txoj kev nkag siab ntawm qhov tsis txaus ntawm T-cell ib puag ncig kom nkag siab zoo dua vim li cas kev ntxhov siab ua rau peb hnyav dua; Tej zaum peb yuav tuaj yeem nrhiav txoj hauv kev tshiab kom cov beta-blockers tuaj yeem siv los tsim cov tshuaj tua kab mob T-hlwb uas muaj peev xwm tiv taus kev depletion thiab pab tiv thaiv qog noj ntshav zoo dua, hais tias tus kws tshawb fawb Globig. Txij li cov beta-blockers tam sim no tau siv dav hauv tsev kho mob, cov kws tshawb fawb tseem vam tias yuav siv thiab tawm tswv yim tshiab los tiv thaiv kab mob qog noj ntshav hauv cov neeg mob qog noj ntshav sai li sai tau, thiab los ntawm kev koom tes nrog cov kws kho mob, cov kws tshawb fawb vam tias yuav kawm ntau cov qauv ntaub so ntswg los ntawm tib neeg cov neeg mob qog noj ntshav. txhawm rau txhawb cov kev tshawb pom thiab muab pov thawj ntxiv ntawm kev ua tau zoo ntawm beta-blockers hauv kev kho mob qog noj ntshav.
Hauv cov ntsiab lus, hauv txoj kev tshawb no, cov kws tshawb fawb tau nthuav tawm cov txheej txheem tshiab uas rov ua kom lub cev muaj peev xwm tawm tsam cov qog los ntawm kev thaiv CD8+ T hlwb.
