Vitamin C, tseem hu ua ascorbic acid, yog cov vitamin tseem ceeb heev rau peb lub cev thiab peb tuaj yeem tau txais los ntawm cov khoom noj xws li citrus, strawberries thiab txiv lws suav. Cov kev tshawb fawb thaum ntxov tau pom tias vitamin C yog ib qho muaj zog antioxidant uas pab txhawm rau tshem tawm cov dawb radicals thiab txo cov cellular puas los ntawm oxidative kev nyuaj siab. Tsis tas li ntawd, vitamin C koom nrog ntau yam kev lom neeg, xws li collagen synthesis thiab antihistamine tso tawm, uas ua lub luag haujlwm tseem ceeb hauv kev noj qab haus huv ntawm daim tawv nqaij thiab kev tiv thaiv kab mob.
Tsis ntev los no, ib txoj kev tshawb fawb loj ntawm kev mob qog noj ntshav tau ua tiav los ntawm Shanghai Second Military Medical University thiab lwm lub koom haum tau nthuav tawm lub luag haujlwm muaj peev xwm ntawm vitamin C hauv kev kho mob qog noj ntshav. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau luam tawm hauv Nature Communications thaum Lub Ib Hlis 4, 2024, nrog cov ntawv hu ua "TET2-cov qog nqaij hlav cGAS ua rau endothelial STING ua kom tswj tau.
Mob qog noj ntshav yog ib qho ntawm cov qog nqaij hlav ntau tshaj plaws thiab yog qhov ua rau thib peb ntawm cov neeg mob qog noj ntshav thoob ntiaj teb. Tam sim no, kev siv tshuaj tiv thaiv kab mob raws li kev tiv thaiv kab mob tiv thaiv kab mob, tshwj xeeb yog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob ntawm tes tuag-1 (PD-1) / programmed cell death ligand 1 (PD-L1) txoj hauv kev, tau ua tiav zoo kawg nkaus hauv kev kho mob. ntau hom qog nqaij hlav malignant, nrog rau kev mob qog noj ntshav siab.
Cov qog nqaij hlav txawv txav thiab qhov tshwm sim hypoxic thiab immunosuppressive qog microenvironment yog qhov tseem ceeb uas cuam tshuam qhov kev ua tau zoo ntawm kev tiv thaiv kab mob, tshwj xeeb tshaj yog nyob rau hauv cov kab mob siab angiogenic hepatocellular carcinomas. Antiangiogenic therapy tsis tsuas yog normalizes qhov txawv txav vasculature thiab txhim kho cov infiltration ntawm lub cev tiv thaiv kab mob nyob rau hauv lub qog, tab sis kuj reverses lub angiogenesis inducer-induced immunosuppressive microenvironment, muab lub laj thawj rau kev sib xyaw ntawm kev kho antiangiogenic thiab kev tiv thaiv kab mob. Txawm li cas los xij, lub vascular normalization lub sij hawm qhov rais ntawm tam sim no anti-angiogenic kho yog nqaim thiab ib ntus, txwv nws augmentation ntawm immunotherapy. Yog li ntawd, cov tswv yim zoo yog qhov yuav tsum tau ceev nrooj los txhim kho cov qog vascular normalization thiab txhim kho kev ua tau zoo ntawm kev siv tshuaj tiv thaiv kab mob.
Mob qog noj ntshav yog ib qho ntawm cov qog nqaij hlav ntau tshaj plaws thiab yog qhov ua rau thib peb ntawm cov neeg mob qog noj ntshav thoob ntiaj teb. Tam sim no, kev siv tshuaj tiv thaiv kab mob raws li kev tiv thaiv kab mob tiv thaiv kab mob, tshwj xeeb yog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob ntawm tes tuag-1 (PD-1) / programmed cell death ligand 1 (PD-L1) txoj hauv kev, tau ua tiav zoo kawg nkaus hauv kev kho mob. ntau hom qog nqaij hlav malignant, nrog rau kev mob qog noj ntshav siab.
Cov qog nqaij hlav txawv txav thiab qhov tshwm sim hypoxic thiab immunosuppressive qog microenvironment yog qhov tseem ceeb uas cuam tshuam qhov kev ua tau zoo ntawm kev tiv thaiv kab mob, tshwj xeeb tshaj yog nyob rau hauv cov kab mob siab angiogenic hepatocellular carcinomas. Antiangiogenic therapy tsis tsuas yog normalizes qhov txawv txav vasculature thiab txhim kho cov infiltration ntawm lub cev tiv thaiv kab mob nyob rau hauv lub qog, tab sis kuj reverses lub angiogenesis inducer-induced immunosuppressive microenvironment, muab lub laj thawj rau kev sib xyaw ntawm kev kho antiangiogenic thiab kev tiv thaiv kab mob. Txawm li cas los xij, lub vascular normalization lub sij hawm qhov rais ntawm tam sim no anti-angiogenic kho yog nqaim thiab ib ntus, txwv nws augmentation ntawm immunotherapy. Yog li ntawd, cov tswv yim zoo yog qhov yuav tsum tau ceev nrooj los txhim kho cov qog vascular normalization thiab txhim kho kev ua tau zoo ntawm kev siv tshuaj tiv thaiv kab mob.
Txoj kev tshawb no pom tau hais tias nyob rau hauv vascular normalization thiab tiv thaiv qog lub cev tiv thaiv kab mob, cGAS hauv cov qog tsis yog nyob ntawm txoj kev STING hauv cov qog, tab sis muaj kev sib raug zoo nrog tus tswv tsev STING. Cov txheej txheem tshwj xeeb yog tias cGAS hauv qog tsim cGAMP, uas tau xa mus rau cov hlwb endothelial los ntawm LRRC8C raws thiab ua kom STING hauv cov hlwb endothelial, yog li txhawb nqa lymphocyte infiltration. Tsis tas li ntawd, cov qog suppressor TET2 ua ke nrog IL-2/STAT5A txoj kev taw qhia los txhawb cGAS gene qhia thiab cGAMP tso tawm hauv cov qog. Thiab vitamin C, raws li TET2 activator, ntxias TET activation, uas nyob rau hauv lem qhib lub qog cGAS-cGAMP-endothelial STING txoj kev thiab txhawb nqa lymphocyte translocation. Qhov kev tshawb pom no tsis tsuas yog muab cov ntsiab lus tseem ceeb rau kev nthuav tawm cov txheej txheem tiv thaiv kab mob hauv cov qog microenvironment, tab sis tseem muab lub hauv paus theoretical rau kev txhim kho yav tom ntej ntawm cov phiaj xwm kho mob raws li qhov axis no.
Tsis tas li ntawd, txoj kev tshawb no tau siv tus qauv qog nas los txheeb xyuas qhov ua kom TET2-STAT5A-cGAS-endothelial STING axis nyob rau hauv cov qog kho cov vitamin C-induced vascular normalization thiab tiv thaiv cell infiltration, thiab pab txhawb kev kho mob ntawm vitamin. C ua ke nrog tshuaj tiv thaiv PD-L1. Qhov kev tshawb pom no nthuav tawm cov txheej txheem ntawm cov vitamin C hauv kev txhim kho cov nyhuv immunotherapeutic thiab txhim kho kev kho mob ntawm kev sib xyaw ua ke ntawm anti-PD-L1, thiab muab lub hauv paus tshiab theoretical rau kev kho tus kheej ntawm cov neeg mob hepatocellular carcinoma.
Tsis tas li ntawd, txoj kev tshawb no tau siv tus qauv qog nas los txheeb xyuas qhov ua kom TET2-STAT5A-cGAS-endothelial STING axis nyob rau hauv cov qog kho cov vitamin C-induced vascular normalization thiab tiv thaiv cell infiltration, thiab pab txhawb kev kho mob ntawm vitamin. C ua ke nrog tshuaj tiv thaiv PD-L1. Qhov kev tshawb pom no nthuav tawm cov txheej txheem ntawm cov vitamin C hauv kev txhim kho cov nyhuv immunotherapeutic thiab txhim kho kev kho mob ntawm kev sib xyaw ua ke ntawm anti-PD-L1, thiab muab lub hauv paus tshiab theoretical rau kev kho tus kheej ntawm cov neeg mob hepatocellular carcinoma.
Ua kom TET2-STAT5A-cGAS-endothelial STING axis hauv cov qog ua kom cov vitamin C-induced vascular normalization thiab tiv thaiv cell infiltration
Duab qhov chaw: https://doi.org/10.1038/s41467-023-43743-9
Duab qhov chaw: https://doi.org/10.1038/s41467-023-43743-9
Txoj kev tshawb no tob tob rau peb txoj kev nkag siab ntawm vitamin C hauv kev kho mob qog noj ntshav los ntawm kev nthuav tawm nws lub luag haujlwm hauv daim siab mob qog noj ntshav. Hauv kev sib piv rau cov kev tshawb fawb yav dhau los, txoj kev tshawb no tsis tsuas yog tsom rau qhov cuam tshuam ncaj qha ntawm vitamin C ntawm daim siab mob qog noj ntshav, tab sis tseem qhia txog nws lub luag haujlwm hauv kev txhawb kev tiv thaiv kab mob. Cov kev tshawb fawb yav dhau los tau tsom mus rau cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob ntawm vitamin C thiab nws cov teebmeem ncaj qha rau cov qog cell loj hlob. Txawm li cas los xij, txoj kev tshawb fawb tam sim no muab kev pom ntau dua los ntawm kev khawb tob rau hauv cov txiaj ntsig ntawm vitamin C ntawm lub cev tiv thaiv kab mob thiab qog microenvironment. Qhov no yuav tsum tau muab cov tswv yim tshiab rau kev tshawb fawb txog kev kho mob qog noj ntshav yav tom ntej, tshwj xeeb tshaj yog nyob rau hauv kev sib xyaw vitamin C ua ke nrog kev tiv thaiv kab mob.
Txawm hais tias txoj kev tshawb fawb no muab kev nkag siab tshiab rau kev siv cov vitamin C hauv kev tiv thaiv kab mob hepatocellular carcinoma, muaj qee qhov kev txwv. Ua ntej, qhov kev sim ntawm txoj kev tshawb fawb no feem ntau yog ua raws li cov qauv tsiaj, thiab ntau qhov kev sim tshuaj yuav tsum tau ua kom paub tseeb tias qhov kev siv ntawm cov kev tshawb pom no hauv tib neeg. Qhov thib ob, txawm hais tias txoj kev tshawb fawb tau npog ntau qhov cuam tshuam ntawm vitamin C ntawm lub cev tiv thaiv kab mob thiab qog microenvironment, kev tshawb nrhiav ntau ntxiv ntawm cov kab mob tiv thaiv kab mob tshwj xeeb thiab cov kev taw qhia tseem xav tau. Cov kev tshawb fawb yav tom ntej tuaj yeem daws cov kev txwv no los ntawm kev nthuav cov qauv loj, qhia ntau hom mob qog noj ntshav rau hauv cov neeg kawm, thiab khawb tob rau hauv cov txheej txheem molecular. Tsis tas li ntawd, cov kws tshawb fawb tuaj yeem tshawb nrhiav qhov cuam tshuam ntawm ntau npaum li cas thiab hom kev tswj hwm ntawm kev kho mob kom zoo rau kev siv cov vitamin C hauv kev tiv thaiv kab mob.
Zuag qhia tag nrho, los ntawm kev tshawb fawb tob tob thiab kev tshawb xyuas cov ntaub ntawv, pab pawg tshawb fawb tau qhia txog lub luag haujlwm tseem ceeb ntawm vitamin C hauv daim siab mob qog noj ntshav, muab cov tswv yim tshiab rau kev kho mob qog noj ntshav yav tom ntej. Txoj kev tshawb no qhib qhov chaw tshiab rau daim ntawv thov ntawm vitamin C, muab ib qho tseem ceeb theoretical thiab kev sim hauv paus rau kev kov yeej kev tiv thaiv kab mob thiab txhim kho cov nyhuv ntawm immunotherapy. Yog li ntawd, vitamin C tsis yog tsuas yog whitening thiab antioxidant, tab sis kuj yog ib tug haib pab nyob rau hauv daim siab mob cancer immunotherapy!
Txawm hais tias txoj kev tshawb fawb no muab kev nkag siab tshiab rau kev siv cov vitamin C hauv kev tiv thaiv kab mob hepatocellular carcinoma, muaj qee qhov kev txwv. Ua ntej, qhov kev sim ntawm txoj kev tshawb fawb no feem ntau yog ua raws li cov qauv tsiaj, thiab ntau qhov kev sim tshuaj yuav tsum tau ua kom paub tseeb tias qhov kev siv ntawm cov kev tshawb pom no hauv tib neeg. Qhov thib ob, txawm hais tias txoj kev tshawb fawb tau npog ntau qhov cuam tshuam ntawm vitamin C ntawm lub cev tiv thaiv kab mob thiab qog microenvironment, kev tshawb nrhiav ntau ntxiv ntawm cov kab mob tiv thaiv kab mob tshwj xeeb thiab cov kev taw qhia tseem xav tau. Cov kev tshawb fawb yav tom ntej tuaj yeem daws cov kev txwv no los ntawm kev nthuav cov qauv loj, qhia ntau hom mob qog noj ntshav rau hauv cov neeg kawm, thiab khawb tob rau hauv cov txheej txheem molecular. Tsis tas li ntawd, cov kws tshawb fawb tuaj yeem tshawb nrhiav qhov cuam tshuam ntawm ntau npaum li cas thiab hom kev tswj hwm ntawm kev kho mob kom zoo rau kev siv cov vitamin C hauv kev tiv thaiv kab mob.
Zuag qhia tag nrho, los ntawm kev tshawb fawb tob tob thiab kev tshawb xyuas cov ntaub ntawv, pab pawg tshawb fawb tau qhia txog lub luag haujlwm tseem ceeb ntawm vitamin C hauv daim siab mob qog noj ntshav, muab cov tswv yim tshiab rau kev kho mob qog noj ntshav yav tom ntej. Txoj kev tshawb no qhib qhov chaw tshiab rau daim ntawv thov ntawm vitamin C, muab ib qho tseem ceeb theoretical thiab kev sim hauv paus rau kev kov yeej kev tiv thaiv kab mob thiab txhim kho cov nyhuv ntawm immunotherapy. Yog li ntawd, vitamin C tsis yog tsuas yog whitening thiab antioxidant, tab sis kuj yog ib tug haib pab nyob rau hauv daim siab mob cancer immunotherapy!
