Hauv ib txoj kev tshawb fawb tshiab, cov kws tshawb fawb los ntawm Indiana Center for Regenerative Medicine thiab Engineering (ICRME) tau txheeb xyuas cov kab mob tshiab, angiogenic fibroblasts (vasculogenic fibroblast), hauv tib neeg thiab nas, muab kev nkag siab tseem ceeb rau kev tsim cov hlab ntsha tshiab thaum xav tau. Cov txiaj ntsig tau luam tawm nyob rau hauv Nature Communications phau ntawv xov xwm thaum Lub Ob Hlis 28, 2023 nrog lub npe "Kev txheeb xyuas lub cev ntawm lub cev vasculogenic fibroblast kom ua tiav cov ntaub so ntswg kho".
Cov hlab ntsha yog tsim los ntawm cov kab mob endothelial, tab sis cov kws sau ntawv no pom tias angiogenic fibroblasts tuaj yeem ua rau cov hlab ntsha tshiab thiab ua tiav cov ntshav. Dr. Chandan K Sen, tus kws sau ntawv xov xwm thiab tus thawj coj ntawm Indiana Regenerative Medicine thiab Engineering Center, tau hais tias, "Ischemic kab mob yog qhov tshwm sim thiab txwv los ntawm cov ntshav tsis txaus- - - - mob ntshav qab zib yog ib qho ntawm lawv. Cov hlab ntsha loj hlob. Txhawm rau kho cov kab mob ischemic, tiv thaiv cov hlab ntsha loj hlob kom txwv cov qog loj hlob, yuav tsum muaj kev nkag siab tag nrho ntawm cov hlab ntsha hauv lub cev.
Cov tib neeg no tau pom cov kab mob angiogenic fibroblasts los ntawm tib neeg cov neeg mob. Thaum ib tug neeg raug mob, lub cev pib tsim angiogenic fibroblasts, uas tsim cov hlab ntsha tshiab los kho cov ntaub so ntswg puas. Tab sis nyob rau hauv qee cov neeg mob, xws li mob ntshav qab zib mellitus, lub peev xwm ua kom cov hlwb tshwj xeeb no ploj zuj zus. Hauv cov qauv kuaj, Sen thiab nws pab neeg tau siv lawv cov ntaub so ntswg nanotransfection (cov ntaub so ntswg nanotransfection, TNT) thev naus laus zis rau cov ntaub so ntswg reprogramming los ntxiv cov angiogenic fibroblasts hauv cov ntaub so ntswg cuam tshuam los ntawm ntshav qab zib. Qhov no tau ua rau kev txhim kho ntawm cov ntshav khiav thiab txhim kho qhov mob ntshav qab zib.
Sen, "Txoj kev tshawb fawb tshiab no tsis yog tsuas yog txheeb xyuas lub xov tooj ntawm tes uas tau ua haujlwm ntsiag to hauv lub cev, tab sis peb tuaj yeem siv TNT thiab cov ntaub so ntswg angiogenic reprogramming los ua kom cov hlwb no thiab cawm cov ntaub so ntswg cuam tshuam los ntawm cov ntshav. "
TNT thiab cov tshuaj kho dua tshiab yog kev lag luam hloov zuj zus thoob ntiaj teb thiab hauv Indiana uas nrhiav kev hloov lossis rov tsim dua tib neeg somatic hlwb, cov ntaub so ntswg, thiab lub cev. Raws li MarketWatch, TNT kev ua lag luam muaj nqis txog $ 2.07 nphom hauv 2020 thiab xav tias yuav loj hlob mus txog $ 7.06 nphom los ntawm 2028, vim tias muaj kev nce ntxiv ntawm cov kab mob dermatology, kab mob ntev thiab mob xwm txheej ceev, thiab kev paub ntau ntxiv txog kev ua haujlwm zoo hauv lub koom haum.
Sen tau hais tias, "Nyob rau hauv tsawg tshaj li ib ob, ib tug TNT nanochip tsuas yog xa ib qho antisense oligonucleotide rau ntawm daim tawv nqaij los hloov cov tawv nqaij fibroblasts rau hauv angiogenic fibroblasts. Cov thev naus laus zis tshiab no tseem qhia cov lus cog tseg hauv kev muab kev kho mob yooj yim thiab zoo rau ntau yam teeb meem kev noj qab haus huv hauv ntau qhov sib txawv. xwm txheej."
