Kaum Ib Hlis 9, 2022 -- Merck tshaj tawm tias nws cov PD-1 inhibitor, Parbolizumab (lub npe lag luam: Kerida ®️) tau pom zoo los ntawm National Medical Products Administration ntawm Tuam Tshoj (NMPA) los muab tshuaj tua kab mob nrog kev kho neoadjuvant thiab txuas ntxiv mus. parbolizumab monotherapy tom qab phais rau kev kho mob thaum ntxov muaj kev pheej hmoo siab triple tsis zoo mob qog noj ntshav mis (TNBC) cov neeg mob qog nqaij hlav PD-L1 (ua ke cov qhab nia zoo (CPS) Ntau dua lossis sib npaug rau 20) los ntawm kev kuaj pom zoo. Qhov kev pom zoo ntawm qhov kev qhia tshiab no yog ua raws li cov ntaub ntawv los ntawm Phase III KEYNOTE-522 kev kawm.
Nov yog 10th qhia pom zoo rau pabolizumab hauv Suav teb:
① Kev kho mob thib ob ntawm melanoma siab heev
② Advanced NSCLC nrog PD-L1 qhia Ntau dua lossis sib npaug li 1 feem pua thiab tsis muaj EGFR/ALK hloov pauv tau kho nrog kev kho thawj kab
③ Ua ke ua ntej-kab tshuaj khomob rau qib siab uas tsis yog-squamous NSCLC yam tsis muaj EGFR / ALK hloov pauv
④ Ua ke nrog thawj kab kws khomob rau qib siab squamous NSCLC
⑤ Kev kho mob thib ob ntawm kev mob qog noj ntshav esophageal
⑥ Kev kho mob thawj zaug rau lub taub hau thiab caj dab squamous cell carcinoma nrog CPS Ntau dua lossis sib npaug rau 20
⑦ Kev kho thawj kab ntawm MSI-H/dMMR mob qog noj ntshav
⑧ thawj kab kho mob qog noj ntshav esophageal
⑨ Kev kho mob thib ob ntawm kab mob hepatocellular carcinoma
⑩ Kev kho mob thawj zaug rau kev pheej hmoo siab triple negative mis cancer (TNBC) nrog CPS Ntau dua lossis sib npaug rau 20
Mob qog noj ntshav mis yog ib qho ntawm cov qog nqaij hlav qog nqaij hlav hauv cov poj niam, qhov tshwm sim uas yog thawj tus poj niam cov qog nqaij hlav, ua rau muaj kev phom sij loj rau cov poj niam cev xeeb tub thiab mob hlwb. Triple negative mis cancer (TNBC) yog ib hom mob qog noj ntshav mis nrog qhov tsis zoo ntawm cov tshuaj estrogen receptor (ER), progesterone receptor (PR) thiab human epidermal growth factor receptor-2 (HER-2), thiab muaj cov Qhov tshwm sim phem tshaj plaws ntawm txhua hom mob qog noj ntshav mis. TNBC feem ntau tshwm sim rau cov poj niam hnub nyoog qis dua 40. 4, TNBC feem ntau cuam tshuam ntau dua, ua rau rov tshwm sim ntxov thiab metastasis, thiab muaj qhov tsis zoo. Qhov kev pheej hmoo ntawm kev rov tshwm sim ntawm TNBC nce mus txog qhov siab tshaj plaws hauv 1 txog 3 xyoos tom qab kuaj pom, thiab qhov kev pheej hmoo ntawm kev tuag hauv 5 xyoos kuj tseem siab dua li lwm hom mob qog noj ntshav mis, uas ua rau muaj mob hnyav rau cov neeg mob.
Kev pom zoo ntawm qhov kev qhia tshiab ntawm pabolizumab hauv Suav teb qhib txoj kev tshiab rau kev kho mob qog noj ntshav hauv kev mob qog noj ntshav mis, uas xav tias yuav coj cov kev xaiv tshiab thiab kev cia siab rau ntau tus neeg mob thiab tsev neeg.
