Tsis ntev los no, raws li Shanghai Hengrui Pharmaceutical Co., LTD., ib lub chaw muag khoom ntawm Henrui Pharmaceutical, anti-A monoclonal antibody SHR-1707 txhaj tshuaj rau kev kho mob ntawm Alzheimer's Disease thaum ntxov (AD) ua tiav thawj tus neeg mob rau npe thiab kev tswj hwm. nyob rau hauv Thawj Tsev Kho Mob ntawm University of Science thiab Technology ntawm Tuam Tshoj.
Qhov kev tshawb fawb soj ntsuam no (CTR20223438) yog tsim los soj ntsuam kev nyab xeeb thiab kev ua siab ntev ntawm SHR-1707 hauv AD-derived me ntsis kev paub tsis ua haujlwm (mildcognitionimpairment, MCI) thiab cov neeg mob AD me me thiab pib tshawb nrhiav lub peev xwm ntawm lub hlwb tshem tawm ntawm -amyloid ( Amyloidbeta, A). Txoj kev tshawb no tau coj los ntawm Thawj Tsev Kho Mob ntawm USTC ntawm Tuam Tshoj nrog 11 lub chaw.
Xyoo 2022, SHR-1707 tau ua tiav ib qho kev kuaj mob ib zaug ntawm kev nce toj hauv cov neeg noj qab haus huv hauv Suav teb thiab Australia. Ob theem kuv kev tshawb fawb no tau pom tias muaj kev nyab xeeb zoo thiab kev zam ntawm ib koob ntawm SHR -1707 txij li 2mg / kg txog 60 mg / kg hauv Suav thiab Australians. Tom qab ob qhov kev tshawb fawb soj ntsuam no, Hengrui Pharmaceutical tau pib txoj kev tshawb fawb ntawm cov neeg mob AD.
Txoj kev tshawb no los ntawm thawj lub tsev kho mob koom nrog Tuam Tshoj University of Science thiab Technology xibfwb ShiJiong, nws tau hais tias: "raws li kev txheeb cais tsis tiav, tam sim no peb lub tebchaws muaj ze li kaum lab tus neeg mob Alzheimer's disease, tab sis rau tus kab mob hauv Suav teb yog kev kho mob, tsis muaj qhov ua rau. Kev kho mob, tam sim no tsuas yog hauv Tebchaws Meskas tau pom zoo ob qho tshuaj tiv thaiv amyloid tshuaj tiv thaiv kab mob, yog li muaj ntau qhov kev xav tau kho mob tsis txaus ntseeg Henrui pab pawg tsim thawj qhov kev ywj pheej ywj pheej ntawm cov tshuaj tiv thaiv amyloid, peb zoo siab heev nrog Henrui pab pawg tsim kho kev sim tshuaj. , los ntawm txoj haujlwm thiab kev tshuaj xyuas kev ncaj ncees, thiab thawj qhov kev kawm, peb yuav ua kom 1707 kev tshawb fawb soj ntsuam kev sim, sai li sai tau kom coj tau ntau tus neeg mob alzheimer's kab mob nrog cov kev xaiv kho tshiab. "
Dr. Jiang Ningjun, tus lwm thawj saib xyuas thiab tus thawj coj zoo ntawm Jiangsu Hengrui Pharmaceutical Co., Ltd., tau hais tias, "SHR-1707 yog A monoclonal antibody targeting A , uas ua rau cov neeg mob poob qis los ntawm kev txo qis. ntawm A nyob rau hauv lub hlwb tsis muaj lub hom phiaj tshuaj tau pom zoo nyob rau hauv Suav teb Raws li peb cov ntaub ntawv uas tsis yog kev kho mob yav dhau los thiab cov txiaj ntsig ntawm kev tshawb fawb soj ntsuam, Hengrui Pharma tau nthuav tawm txoj kev tshawb fawb sai sai, vam tias yuav pom kev nyab xeeb thiab cov txiaj ntsig ua ntej hauv txoj kev tshawb no. , yog li txhawm rau thawb cov tshuaj mus rau theem III kawm sai dua thiab nqa cov tshuaj tshiab no rau cov neeg mob coob hauv Suav teb. "
SHR -1707 txhaj tshuaj yog los ntawm cov chaw muag tshuaj tsis tu ncua Shanghai kws tshuaj co., LTD., kev tshawb fawb ywj pheej thiab kev txhim kho humanized anti-A monoclonal antibody (IgG 1 subtype), tuaj yeem tiv thaiv A plaque los ua ke lossis qhib microglia nqos ntau hom A. , yog li txo qis A qib hauv cov neeg mob AD nrog AD, ncua kev paub txog kev ua haujlwm tsis zoo thiab tswj kev kis tus kab mob. Thaum Lub Peb Hlis 2021, SHR-1707 Kev Txhaj Tshuaj tau txais Daim Ntawv Ceeb Toom Txog Kev Pom Zoo Tshuaj Kho Mob uas tau muab los ntawm Lub Xeev Food and Drug Administration, thiab tau pom zoo ua cov kev tshawb fawb soj ntsuam nrog qhov qhia txog AD.
