Ib qho tshuaj tau pom zoo rau kev kho mob cem quav (mob cem quav) uas tuaj yeem ua rau qeeb lub cev mob cuam tshuam nrog tus mob, tsis ntev los no, luam tawm nyob rau hauv ib txoj kev tshawb fawb hu ua "Intestinal neuropod cell GUCY2C tswj qhov mob visceral" hauv phau ntawv xov xwm thoob ntiaj teb Journal of Clinical Investigation, Cov kws tshawb fawb. los ntawm Thomas Jefferson University thiab lwm lub tsev kawm ntawv tau pom tias, Txoj kev ntawm kev ua ntawm cov tshuaj yuav raug muab cais tawm ntawm cov tshuaj lom neeg, qhov kev tshawb pom yuav muaj peev xwm pab txhim kho cov kev kho tshiab kom meej meej lub hom phiaj ntawm qhov mob visceral (visceral mob syndromes) uas tsis yog cem quav.
Cov kws tshawb fawb tau hais tias, muaj nyob hauv plab hu ua GUCY2C receptor molecules tuaj yeem tswj hwm lub cev dej thiab ntsev sib npaug, uas tuaj yeem kho qhov muag ntawm cov quav, hu ua linalol peptide (linaclotide) cov tshuaj cem quav tuaj yeem ua rau cov receptor kom nce cov dej tso tawm, txawm li cas los xij. , qhov mob ntawm cov tshuaj zoo li tsis yog qhov tshwm sim yooj yim ntawm kev tshem tawm cem quav, thiab hais txog yuav ua li cas tag nrho cov haujlwm no, cov kws tshawb fawb tau muab ntau yam kev xav. Cov kws tshawb fawb Waldman li al tau pib qhia meej tias cov tshuaj tsom mus rau GUCY2C receptors nyob rau hauv ib qho kev tshawb pom tshiab hauv plab hnyuv cell paj hlwb (neuropods) cell uas hnov cov stimuli thiab sib txuas lus nrog cov neurons uas xa cov lus mob rau lub hlwb.
Hauv txoj kev tshawb no, cov kws tshawb fawb siv cov cuab yeej molecular los ntawm nas "cov paj hlwb" hlwb (tsis yog lwm cov kab mob hauv plab) los ntawm GUCY2C receptor, cov tsiaj hloov pauv yuav muaj qhov mob visceral, thiab cov tshuaj linarpeptide tsis txo cov tsos mob ntawm tus tsiaj, tib lub sijhawm. , cov dej tso tawm ntawm lub cev tsis cuam tshuam, qhov no txhais tau hais tias "cov paj hlwb" cell receptor tuaj yeem tswj cov hnyuv, tab sis kuj kho cov teebmeem ntawm cov tshuaj ntawm lub cev mob. Ua rau cov neeg tshawb nrhiav xav tsis thoob, vim li cas qhov kev faib tawm no txawv heev. Nws paub zoo tias kev ua haujlwm lom neeg muaj qee yam rov ua dua, thiab kev tshawb nrhiav kev tshawb fawb feem ntau tsis tsim cov txiaj ntsig zoo li no, uas tuaj yeem cais ob txoj haujlwm zoo li cuam tshuam, mob nyem thiab dej tso tawm.
Cov kws tshawb fawb tau hais tias Waldman, peb xav txog yuav ua li cas los txhim kho lub hom phiaj ncaj qha "cov paj hlwb" kev kho mob ntawm tes, peb kuj tseem tuaj yeem zam lwm yam mob visceral uas pom tias muaj kev phiv loj, xws li raws plab, piv txwv li, nrog kev mob plab ntawm plab hnyuv lossis endometriosis, "nerve pod" hlwb tswj kev mob visceral tuaj yeem sawv cev rau "txoj kev dhau los". Hauv kev xaus, peb cov txiaj ntsig tau pom tias thaum tsis muaj GUCY2C cov tshuaj hormones hauv cov neeg mob uas muaj qhov mob visceral, cov kws tshawb fawb qhia txog lub luag haujlwm tseem ceeb thiab tshwj xeeb ntawm "cov paj hlwb" cellular GUCY2C teeb liab hauv cov kab mob pathophysiological thiab txhim kho kev kho mob hauv cov mob no.
