Http://china.chemnet.com/2022-03-30 09:27:27 xinhua nyiaj txiag
Thaum Lub Peb Hlis 25, 2022, Jemincare Group tau tshaj tawm hauv Shanghai tias daim ntawv thov kuaj mob (IND) rau JYB1904 Txhaj, ib qho tshiab los tiv thaiv IgE recombinant humanized monoclonal antibody tsom txoj kev kho xa los ntawm jiangsu Jiye Biopharmaceutical Co., LTD., ib lub koom haum ntawm Jemincare Group , tau pom zoo los ntawm Lub Chaw Ntsuam Xyuas Tshuaj (CDE) ntawm Lub Xeev Food and Drug Administration ntawm Tuam Tshoj.
JYB1904 yog tus kheej tsim los ntawm Shanghai Jiyu Pharmaceutical Technology Co., LTD., ib lub koom haum ntawm Jemincare, thiab yog chav kawm 1 cov tshuaj tshiab ntawm cov khoom siv roj ntsha nrog cov cai muaj tswv yim ywj pheej. Daim ntawv thov rau kev sim tshuaj tau txais los ntawm CDE thaum Lub Ib Hlis 14, 2022, thiab kev pom zoo tacit rau kev sim tshuaj tau txais hauv 70 hnub nkaus xwb.
IgE yog lub ntsiab immunoglobulin mediating hom I hypersensitivity kab mob. Thaum lub cev raug rau cov allergen, cov allergen tuaj yeem khi rau IgE khi rau ntawm cov nyhuv ntawm tes FcεRI thiab sib txuas sib txuas ua ke los tsim crosslinking, ua rau kev tso tawm cov kab mob inflammatory thiab ua rau muaj ntau yam kev tsis haum tshuaj.JYB1904 tuaj yeem tshwj xeeb. khi rau dawb IgE, yog li thaiv kev khi ntawm IgE rau nws cov receptor FcεRI, yog li tiv thaiv nws txoj kev ua kom tsis zoo los ntawm kev ua xua, uas xav kom txo cov tsos mob ntawm cov neeg mob sai thiab zoo hauv kev kho mob.
Hauv kev tshawb fawb preclinical, JYB1904 tau pom zoo bioactivity, pharmacodynamics, thiab stability piv nrog omalzumab taub hau mus rau lub taub hau, nrog rau kev pib sai thiab ua tau zoo nyob rau hauv cov tsiaj qauv ntawm mob hawb pob, zoo kev nyab xeeb nyob rau hauv cov tsiaj, thiab ntev serum ib nrab-lub neej.Cov kev tshwm sim qhia tias JYB1904 txhaj tshuaj. muaj peev xwm kho tau zoo heev thiab tuaj yeem muab kev kho mob tshiab rau kev mob ntsws asthma nruab nrab thiab hnyav thiab lwm yam kab mob ua xua.
Tam sim no, Jemincare tau ua tiav cov phiaj xwm kev kho mob hauv tsev ntawm JYB1904, txhawm rau ua kom sai sai rau theem kho mob kuv sim.Peb tos ntsoov rau qhov tuaj txog thaum ntxov ntawm cov khoom los coj xov xwm zoo rau cov neeg mob.
Shanghai Jiyu Pharmaceutical Technology Co., LTD., ib lub koom haum ua lag luam tag nrho ntawm Jemincare Group, tau cog lus los ua ib lub chaw tshuaj R & D nrog rau lub ntiaj teb kev cuam tshuam. Nws R & D pipeline npog cov tshuaj tshiab ntawm cov tshuaj lom neeg macromolecules, cov tshuaj tshiab ntawm cov tshuaj me me molecules, cov tshuaj suav tshuaj tshiab tshiab, txoj kev coj ua thiab kev npaj siab kawg. Nws tau cog lus tias yuav ua rau muaj kev cuam tshuam hauv kev kho mob nephropathy, qog nqaij hlav, mob plawv, hlab ntsha, ua pa, tiv thaiv kab mob, menyuam yaus, mob thiab lwm yam.Cov kev tshawb fawb thiab kev loj hlob ntawm JYB1904 txhaj tshuaj yog coj los ntawm lub koom haum ntawm Loj Molecule Innovative Drugs. lub tuam txhab. Lub koom haum muaj nws tus kheej tib neeg lub tsev qiv ntawv tshuaj tiv thaiv kab mob ntawm 70 billion qib FeiJie thiab nws tus kheej tsim feiTai antibody discovery platform. Ntau cov tshuaj tiv thaiv kab mob tau nkag mus rau IND lossis IND daim ntawv thov npaj theem.Tam sim no, JMB2002, tus tshiab coronavirus Omicron neutralizing antibody nws tus kheej tsim los ntawm lub tsev kho mob, tau ua tiav theem I kev sim tshuaj. Cov kev tshawb fawb tshiab tau lees paub tias JMB2002 muaj kev ua haujlwm tsis zoo tiv thaiv tus kabmob tshiab Omicron variant, thiab cov txiaj ntsig cuam tshuam tau luam tawm hauv Science.
Jemincare Group tau tsim nyob rau xyoo 1999, lub hauv paus hauv Nanchang, Tuam Tshoj, cov khoom tseem ceeb pipeline rau cov kab mob hauv lub raum, qog, plawv-cerebrovascular, ua pa tiv thaiv kab mob, mob tsib cheeb tsam, tau cog lus los muab cov neeg mob nrog cov tshuaj zoo thiab cov tshuaj kho tshiab. .Raws li ib qho ntawm cov pab pawg kws kho mob niaj hnub hauv Suav teb, Jemincare Group tau raug ranked ntawm kaum sab saum toj ntawm Tuam Tshoj txoj kev lag luam tshuaj rau ntau xyoo sib law liag.
[Daim ntawv ceeb toom Copyright] Source chemical Network; Nyob rau tib lub sijhawm, peb tawm tswv yim kev hwm thiab kev tiv thaiv cov cuab yeej cuab tam txoj cai, yog tias koj pom muaj teeb meem kev cai lij choj hauv lub vev xaib no, thov xa koj cov lus nug txog kev cai lij choj, daim ntawv pov thawj kev tso cai, daim ntawv pov thawj kev cai lij choj, cov ntaub ntawv tiv toj rau lub vev xaib official email, peb yuav txheeb xyuas thiab lees paub. nrog thawj zaug.
