Hnub no (Lub Xya Hli 11), CDE lub vev xaib official tau qhia tias Zhejiang Heze Pharmaceutical Technology Co., Ltd. (tom qab no hu ua "Heze Pharmaceutical") txhaj tshuaj HZ012 tau txais kev tso cai los ntawm kev sim tshuaj rau cov neeg laus nrog BMI ntawm 28kg / m2. thiab siab dua (kev rog) lossis BMI ntawm 24kg / m2 thiab siab dua (hnyav) thiab nrog tsawg kawg ib qho teeb meem rog rog los pab cov zaub mov tsis muaj calorie thiab nce kev tawm dag zog rau kev tswj qhov hnyav.
HZ012 yog GLP-1R/GIPR dual agonist tsim nyob rau hauv kev coj noj coj ua ntawm Heze Pharmaceutical.
Ntxiv rau HZ012, Heze Pharmaceutical kuj muaj ob lub GLP-1R/GIPR agonists, uas yog HZ010 thiab P29. Ntawm lawv, HZ010 tau koom ua ke tsim los ntawm Doyle Biotech thiab Heze Pharmaceuticals, thiab Phase I kev sim tshuaj tau ua thaum Lub Kaum Hli 2022. P29 kuj tau pom zoo rau kev kho mob hauv lub Plaub Hlis xyoo no. Ob qho tshuaj yog npaj los kho mob ntshav qab zib hom 2.
HZ012 tau pom zoo rau kev siv tshuaj kho mob lub sijhawm no, nrog rau qhov qhia txog kev rog. HZ012 kuj yog thawj GLP-1R/GIPR agonist tau pom zoo los ntawm Heze Pharmaceutical los ua qhov kev sim tshuaj rog rog.
Ntxiv rau HZ012, Heze Pharmaceutical kuj muaj ob lub GLP-1R/GIPR agonists, uas yog HZ010 thiab P29. Ntawm lawv, HZ010 tau koom ua ke tsim los ntawm Doyle Biotech thiab Heze Pharmaceuticals, thiab Phase I kev sim tshuaj tau ua thaum Lub Kaum Hli 2022. P29 kuj tau pom zoo rau kev kho mob hauv lub Plaub Hlis xyoo no. Ob qho tshuaj yog npaj los kho mob ntshav qab zib hom 2.
HZ012 tau pom zoo rau kev siv tshuaj kho mob lub sijhawm no, nrog rau qhov qhia txog kev rog. HZ012 kuj yog thawj GLP-1R/GIPR agonist tau pom zoo los ntawm Heze Pharmaceutical los ua qhov kev sim tshuaj rog rog.
40 xyoo lub hom phiaj: dov mus rau hauv txoj kev tshiab ntawm kev poob phaus
GLP-1 receptor yog ib lub hom phiaj tseem ceeb rau kev kho mob ntshav qab zib hom 2 rau ntau tshaj 40 xyoo. GLP-1 yog ib hom kab mob pancreatic stimulating hormone uas tuaj yeem siv los ntawm nws tus kheej hauv kev kho mob, nrog rau kev xaiv lub cev thiab ob peb yam kev mob tshwm sim.
Nrog rau qhov muaj koob meej ntawm Smeglutide's "magic effect" ntawm kev poob phaus, qhov "lub hom phiaj qub" ntawm ntshav qab zib tau raug sau tseg tias "yuag poob". Xyoo 2022, Novo Nordisk, vam khom rau Smeaglutide, yuav yeej 10 billion US dollars, ntxiv rau kev tshawb fawb thiab kev loj hlob ntawm GLP-1 tshuaj.
Hais txog kev poob phaus, ntxiv rau smectide, lwm yam tshuaj kuj ua tau zoo.
Xyoo 2022, GLP-1/GIP dual agonist tilporide tau pom zoo rau kev lag luam hauv Tebchaws Meskas rau kev kho mob ntshav qab zib hom 2. Tilposide ua tiav kev muag khoom ntawm $ 568.5 lab hauv tsawg dua ib xyoos; Hauv thawj peb lub hlis twg ntawm 2023, nws tau mus txog 536.4 lab nyiaj daus las, nrog rau qhov kev loj hlob txaus ntshai.
Nrog rau qhov muaj koob meej ntawm Smeglutide's "magic effect" ntawm kev poob phaus, qhov "lub hom phiaj qub" ntawm ntshav qab zib tau raug sau tseg tias "yuag poob". Xyoo 2022, Novo Nordisk, vam khom rau Smeaglutide, yuav yeej 10 billion US dollars, ntxiv rau kev tshawb fawb thiab kev loj hlob ntawm GLP-1 tshuaj.
Hais txog kev poob phaus, ntxiv rau smectide, lwm yam tshuaj kuj ua tau zoo.
Xyoo 2022, GLP-1/GIP dual agonist tilporide tau pom zoo rau kev lag luam hauv Tebchaws Meskas rau kev kho mob ntshav qab zib hom 2. Tilposide ua tiav kev muag khoom ntawm $ 568.5 lab hauv tsawg dua ib xyoos; Hauv thawj peb lub hlis twg ntawm 2023, nws tau mus txog 536.4 lab nyiaj daus las, nrog rau qhov kev loj hlob txaus ntshai.
Thaum Lub Plaub Hlis 2022, Lilly tau tshaj tawm cov ntaub ntawv tseem ceeb los ntawm lub ntiaj teb theem 3 kev sim tshuaj tilposide hauv kev kho mob rog lossis rog rog. Cov txiaj ntsig tau pom tias peb koob tshuaj tilposide (5mg, 10mg, 15mg) hauv pab pawg kho mob tau muaj txiaj ntsig zoo dua qhov hnyav dua li cov placebo tswj pawg ntawm 72 lub lis piam. Nyob rau tib lub sijhawm, pawg pab pawg tau txais koob tshuaj ntau tshaj (15mg) ntawm kev kho mob tau poob qhov hnyav ntawm 22.5% (kwv yees li 24 kilograms), nrog rau 63% ntawm cov neeg mob tau poob qis tsawg kawg yog 20%. Tilposide yog thawj cov tshuaj nyob rau theem 3 kev sim tshuaj kom txo lub cev hnyav los ntawm qhov nruab nrab ntawm ntau dua 20%.
Hauv lwm lo lus, qhov hnyav poob ntawm Tilposide zoo dua li ntawm Smegglutide.
Hauv Suav teb, telposide tseem nyob rau theem kho mob. Thaum Lub Ob Hlis Ntuj xyoo no, Lilly tau tshaj tawm cov txiaj ntsig zoo hauv theem III kev sim tshuaj telposide rau cov neeg laus rog rog lossis rog rog hauv Suav teb. Hauv kev sim, tag nrho kev nyab xeeb ntawm Tilposide zoo ib yam li cov ntawv qhia kev sim yav dhau los.
Ntxiv nrog rau cov tshuaj tau hais los saum no, Rita Lilly's GLP{0}}R/GIPR/GCGR triple inhibitor Retarutide kuj tsim nyog tos ntsoov rau.
Tsis ntev los no, phau ntawv xov xwm kho mob saum toj kawg nkaus, New England Journal of Medicine, tau tshaj tawm cov txiaj ntsig ntawm qhov kev sim thib ob ntawm Retatrutide, uas pom tau tias cov tshuaj no tuaj yeem txo qhov hnyav ntawm cov ntsiab lus los ntawm 24.2% hauv 48 lub lis piam, tshaj tag nrho cov tshuaj poob phaus. .
Hauv lwm lo lus, qhov hnyav poob ntawm Tilposide zoo dua li ntawm Smegglutide.
Hauv Suav teb, telposide tseem nyob rau theem kho mob. Thaum Lub Ob Hlis Ntuj xyoo no, Lilly tau tshaj tawm cov txiaj ntsig zoo hauv theem III kev sim tshuaj telposide rau cov neeg laus rog rog lossis rog rog hauv Suav teb. Hauv kev sim, tag nrho kev nyab xeeb ntawm Tilposide zoo ib yam li cov ntawv qhia kev sim yav dhau los.
Ntxiv nrog rau cov tshuaj tau hais los saum no, Rita Lilly's GLP{0}}R/GIPR/GCGR triple inhibitor Retarutide kuj tsim nyog tos ntsoov rau.
Tsis ntev los no, phau ntawv xov xwm kho mob saum toj kawg nkaus, New England Journal of Medicine, tau tshaj tawm cov txiaj ntsig ntawm qhov kev sim thib ob ntawm Retatrutide, uas pom tau tias cov tshuaj no tuaj yeem txo qhov hnyav ntawm cov ntsiab lus los ntawm 24.2% hauv 48 lub lis piam, tshaj tag nrho cov tshuaj poob phaus. .
Cov ntsiab lus luv luv
Tsis ntev dhau los, Liraglutide txhaj tshuaj ntawm Huadong tau pom zoo raws li ib qho kev qhia rau poob phaus; Tsuas yog nyob rau hauv Suav teb, ntau tshaj kaum GLP-1 inhibitors tau thov kom poob phaus, xws li HS-20094 ntawm Hansen Pharmaceutical, HRS9531 ntawm Jiangsu Hengrui Tshuaj, GMA-106 ntawm Hongyun Huaning thiab GZR -18 ntawm Ganli Pharmaceutical. Kev sib tw hauv kev ua lag luam poob qis hauv kev lag luam yog nce zuj zus, thiab HZ012 nyuam qhuav pib. Qhov kev ua tau zoo kawg yuav ua li cas, peb tuaj yeem tos thiab pom.
