H. pylori yog qhov tseem ceeb ntawm kev pheej hmoo rau mob qog noj ntshav hauv plab thiab tau teev tseg raws li Class I carcinogen. Tus kab mob Helicobacter pylori tuaj yeem txhawb kev mob plab, atrophy, thiab plab hnyuv metaplasia (IM). Ntawm cov neeg mob Helicobacter pylori, tsuas yog 1% -3% thaum kawg tsim GC, qhia txog kev koom tes ntawm lwm yam tshwm sim. Cov pov thawj tshiab qhia tau hais tias muaj qhov tseem ceeb ntawm cov tsis yog Helicobacter pylori microbiota nyob rau hauv lub plab mucosa, thiab lawv cov dysregulation tuaj yeem ua lub luag haujlwm hauv kev txhim kho mob qog noj ntshav. Txawm li cas los xij, kev txheeb xyuas thiab tus cwj pwm ntawm cov tsis yog Helicobacter pylori tsav cov kab mob cuam tshuam nrog mob qog noj ntshav tseem yuav tsum tau tshawb nrhiav.
Tsis ntev los no, xibfwb Kaili Fu thiab nws pab neeg los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Li Ka shing Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv, Suav University of Hong Kong, Hong Kong, tau qhia txog lub plab microbiome ntawm Helicobacter pylori cov neeg mob tsis zoo ntawm ntau theem ntawm cov qog nqaij hlav. Qhov tshwm sim, los ntawm kev mob plab sab nraud, atrophic gastritis, IM mus rau GC, nrog rau lub hom phiaj ntawm kev tshawb nrhiav qhov tsis yog Helicobacter pylori gastric microbiome, Thiab nws tau qhia tias Amanita yog cov kab mob uas txhawb kev loj hlob ntawm cov qog nqaij hlav hauv plab los ntawm kev sib cuam tshuam ncaj qha nrog lub plab epithelial hlwb ntawm TMPC- ANXA2-MAPK axis.
Cov txiaj ntsig tau pom tias Haemophilus parasuis yooj yim colonized nyob rau hauv lub plab ntawm nas thiab ua rau ib tug mob inflammatory teb, ua rau upregulation ntawm pro-inflammatory cytokines xws li Ccl20 thiab Ccl8, thiab tom qab ntawd nkag mus rau hauv lub sij hawm ntev, ua rau muaj mob hnyav thiab mob gastritis. Cov kab mob ntev ntev nrog Streptococcus tuaj yeem ua rau mob plab hnyuv loj. Qhov nce ntawm Alcian xiav zoo hlwb thiab GSII zoo mucinous caj dab hlwb, nrog rau qhov txo qis ntawm gastric intrinsic factor (GIF) cov thawj coj zoo hlwb, qhia tau tias Streptococcus tuaj yeem ua rau degeneration thiab hloov pauv.
Kev kis tus kab mob Streptococcus suis thaum lub sij hawm precancerous kuj tuaj yeem ua rau muaj kev nce hauv plab pH thiab kev hloov pauv hauv plab hnyuv microbiota, txhim kho cov kab mob hauv lub qhov ncauj symbiotic (Prevotella thiab Aggregatibacter), thiab probiotics B Pseudolongum depleted. Hauv MNU qauv, angiostreptococci yuav ua rau muaj kev hloov pauv ntawm dysplasia thiab nce qhov tshwm sim ntawm cov qog nqaij hlav hauv plab, thiab tus kab mob angiostreptococcal yuav ua rau muaj kev loj hlob ntawm tes hauv plab hnyuv thiab qog. Kev nthuav qhia ntawm cov cim kaw ntom nti CLDN18, OCLN, thiab ZO-1 txo qis thaum lub sijhawm, thiab kev kis tus kab mob Haemophilus parasuis tuaj yeem ua rau lub plab ua haujlwm tsis zoo.
Tsis ntev los no, xibfwb Kaili Fu thiab nws pab neeg los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Li Ka shing Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv, Suav University of Hong Kong, Hong Kong, tau qhia txog lub plab microbiome ntawm Helicobacter pylori cov neeg mob tsis zoo ntawm ntau theem ntawm cov qog nqaij hlav. Qhov tshwm sim, los ntawm kev mob plab sab nraud, atrophic gastritis, IM mus rau GC, nrog rau lub hom phiaj ntawm kev tshawb nrhiav qhov tsis yog Helicobacter pylori gastric microbiome, Thiab nws tau qhia tias Amanita yog cov kab mob uas txhawb kev loj hlob ntawm cov qog nqaij hlav hauv plab los ntawm kev sib cuam tshuam ncaj qha nrog lub plab epithelial hlwb ntawm TMPC- ANXA2-MAPK axis.
Cov txiaj ntsig tau pom tias Haemophilus parasuis yooj yim colonized nyob rau hauv lub plab ntawm nas thiab ua rau ib tug mob inflammatory teb, ua rau upregulation ntawm pro-inflammatory cytokines xws li Ccl20 thiab Ccl8, thiab tom qab ntawd nkag mus rau hauv lub sij hawm ntev, ua rau muaj mob hnyav thiab mob gastritis. Cov kab mob ntev ntev nrog Streptococcus tuaj yeem ua rau mob plab hnyuv loj. Qhov nce ntawm Alcian xiav zoo hlwb thiab GSII zoo mucinous caj dab hlwb, nrog rau qhov txo qis ntawm gastric intrinsic factor (GIF) cov thawj coj zoo hlwb, qhia tau tias Streptococcus tuaj yeem ua rau degeneration thiab hloov pauv.
Kev kis tus kab mob Streptococcus suis thaum lub sij hawm precancerous kuj tuaj yeem ua rau muaj kev nce hauv plab pH thiab kev hloov pauv hauv plab hnyuv microbiota, txhim kho cov kab mob hauv lub qhov ncauj symbiotic (Prevotella thiab Aggregatibacter), thiab probiotics B Pseudolongum depleted. Hauv MNU qauv, angiostreptococci yuav ua rau muaj kev hloov pauv ntawm dysplasia thiab nce qhov tshwm sim ntawm cov qog nqaij hlav hauv plab, thiab tus kab mob angiostreptococcal yuav ua rau muaj kev loj hlob ntawm tes hauv plab hnyuv thiab qog. Kev nthuav qhia ntawm cov cim kaw ntom nti CLDN18, OCLN, thiab ZO-1 txo qis thaum lub sijhawm, thiab kev kis tus kab mob Haemophilus parasuis tuaj yeem ua rau lub plab ua haujlwm tsis zoo.
Vascular Streptococcus colonizes gastric mucosa thiab txhawb kev mob o
Hauv cov ntsiab lus, qhov kev sim no tau txheeb xyuas Streptococcus suis uas tsis yog Helicobacter pylori txhawb txoj kev loj hlob ntawm plab hnyuv thiab elucidated cov tshuaj lom qhov chaw TMPC ntawm Haemophilus parahaemolyticus khi rau ANXA2 ntawm lub plab epithelial hlwb, inducing cov kab mob txuas, ntxeem tau MAP ntawm cov teeb liab, thiab downstreaming activation. Yog li, qhov no muab pov thawj rau Streptococcus suis los ua cov kab mob pathogenic nyob rau theem kev loj hlob ntawm plab hnyuv.
