Nrog rau kev sib kis loj ntawm tus kabmob tshiab, tus kabmob tshiab kabmob kis mus ntxiv, Alpha, Beta, Gamma, Delta, Omicron, thiab lwm yam. Qee cov kabmob mutant no muaj peev xwm kis tau zoo dua lossis muaj zog tiv thaiv kev tiv thaiv, thiab lub ntiaj teb kev txhawj xeeb tshaj plaws yog Omicron mutant hom.
Tsis ntev los no, ntau qhov sib txawv ntawm tus kabmob tshiab Omicjunon tau tshwm sim, suav nrog BQ.1, BQ.1.1, BA.4.6, BF.7 Thiab BA. Cov kev hloov tshiab xws li 2.75.2 nyiam cov neeg nyiam ntawm WHO, uas tuaj yeem muaj peev xwm tiv thaiv kab mob ntau dua.
Xib fwb Liu Shanxue, tus kws kho mob hauv Suav teb ntawm Ohio State University, tau luam tawm ib daim ntawv hauv phau ntawv journal "Cell Host & Microbes" lub npe "" Enhanced Neutralization Resistance of SARS-CoV-2 Omicron Subvariants BQ ".1,BQ.1.1, BA.4.6, BF.7 thiab BA. Cov ntawv tshawb fawb ntawm 2.75.2 ".
Txoj kev tshawb no tau pom tias, piv nrog cov kab mob thaum ntxov BA.1 Thiab BA.4 / 5 Hauv qhov sib piv, tag nrho cov kev hloov pauv tshiab no tau txhim kho lub cev tiv thaiv kab mob, tshwj xeeb tshaj yog BQ uas tau tsav los ntawm N460K thiab K444T kev hloov pauv.1 Thiab BQ.1.1 Variants. , thiab BA, uas tau tsav los ntawm F486S mutation.2.75.2 Variants, muaj peev xwm tiv thaiv kab mob ntau dua, thiab zoo dua ntawm kev zam cov tshuaj tiv thaiv tsis zoo uas tsim los ntawm cov tshuaj tiv thaiv thiab kab mob.
Nyob rau hauv txoj kev tshawb no, cov kws tshawb fawb tau soj ntsuam BQ.1, BQ.1.1, BA.4.6, BF.7 Thiab BA.2.75.2 Variants, muab rau hauv 3 koob tshuaj tiv thaiv, BA.1 Cov neeg mob, BA. Kev khiav tawm muaj peev xwm hauv cov tshuaj tiv thaiv uas tsim tawm hauv 4 / 5 cov neeg mob.
Raws li US CDC cov ntaub ntawv, BA.2.75.2 Qhov txawv yog Omicron BA. Cov mutant ntawm 2, uas yog lub zog tshaj plaws hauv kev khiav tawm ntawm cov tshuaj tiv thaiv kab mob nruab nrab ntawm tag nrho cov kev hloov pauv tau sim, thiab tam sim no, nws sawv cev tsuas yog ib feem me me ntawm cov kab mob tshaj tawm hauv Tebchaws Meskas, BQ.1 Thiab BQ.1.1 Variants tau dhau los ua tus kev mob siab tshaj.
Cov txiaj ntsig tau pom tias peb koob tshuaj tiv thaiv neutralized BQ piv nrog neutralizing cov tshuaj tiv thaiv tiv thaiv tus kab mob qub.1 Thiab BQ. Cov tshuaj tiv thaiv rau 1.1 tau txo los ntawm kwv yees li 20 npaug.
Tsis tas li ntawd, BA.1 Neutralizing cov tshuaj tiv thaiv rau cov neeg mob cov khoom, cov neutralizing titers rau BQ series variant tau qis dua li cov thawj hom kab mob, whereas BA. Rau 4/5 ntawm cov neeg mob, cov tshuaj tiv thaiv kab mob rau BQ variant tsis tau mus txog qib tshawb pom.
BQ.1, BQ.1.1 thiab BA2.75.2 tau pom muaj zog tiv thaiv kev tsis sib haum xeeb
Cov txiaj ntsig tau pom tias cov tshuaj tiv thaiv uas tsim los ntawm cov kab mob thaum ntxov tsis tau zoo tiv thaiv kev kis tus kab mob Omicron nrov tam sim no.
Cov kws tshawb fawb kuj tau tsim cov qauv qauv ntawm tus kheej cov amino acids hloov pauv los ntawm kev hloov pauv tshiab ntawm cov kab mob sib kis, txheeb xyuas qee qhov tseem ceeb ntawm cov molecules rau kev hloov pauv ntawm cov hloov tshiab.
Cov qauv no qhia tias kev hloov pauv N460K tuaj yeem ua rau BQ.1 Thiab BQ.1.1 Kev nkag mus rau hauv cov tswv tsev muaj txiaj ntsig zoo dua, thiab txhim kho lub peev xwm ntawm tus kab mob los khi rau cov tswv tsev cell, uas ua rau muaj tus kab mob pib, nce mus rau cov tsos mob hnyav dua. , thiab tus kab mob kis tau tus kab mob.tab sis BA. Qhov kev tsis sib haum xeeb ntawm 2.75.2 feem ntau yog txiav txim siab los ntawm F486S kev hloov pauv, uas muab lub hauv paus tseem ceeb ntawm kev tshawb fawb rau peb txoj kev nkag siab txog kev tiv thaiv kev tiv thaiv ntawm cov kev hloov pauv no thiab peb cov kev tiv thaiv.
Raws li Beijing Daily, Li Dong, tus kws kho mob ntawm lub chaw ua haujlwm ntawm kev ua pa thiab kis kab mob ntawm lub Tsev Kho Mob Beijing You'an, tau hais tias cov kab mob tseem ceeb hauv Beijing yog Olympic Secret tub rog mutant BF.7. Raws li ib qho ntawm Omicjunon muants, BF.7 yog kis tau zoo heev, nrog cov kab mob kis tau tus mob ntawm 5 - 6 thiab Omicjon variant ntau dua 10.
Tsis tas li ntawd, Okeron mutant muaj zog tiv thaiv kev tiv thaiv kev tiv thaiv thiab kev loj hlob ntawm cov kab mob ua pa sab saud, uas txhais tau hais tias tus neeg mob tuaj yeem tham, hnoos, kis tau ntau dua, cov neeg nyob ib puag ncig yuav kis tau ntau dua, Ojon muaj kab mob me dua, thiab yooj yim. kom txo kev ceev faj.
koom nrog BA.1, BA.2 Thiab BA.5 Piv nrog rau qhov sib txawv, BF.7 muaj kev sib kis ceev ceev thiab muaj peev xwm sib kis tau zoo dua, uas yog qhov muaj zog tshaj plaws ntawm kev sib kis ntawm Omicjunon muants kis hauv Suav teb.
