Nyob rau hauv ib txoj kev tshawb fawb luam tawm nyob rau hauv thoob ntiaj teb phau ntawv journal hlwb muaj cai Brain-derived tau: ib tug tshiab ntshav-raws li biomarker rau Alzheimer-s kab mob-hom neurodegeneration, cov kws tshawb fawb los ntawm University of Gothenburg thiab lwm lub tsev kawm ntawv tau tsim cov txheej txheem tshiab nrhiav kom pom cov neuromarkers ntawm Alzheimer's kab mob hauv cov neeg mob cov ntshav kuaj. Qhov no lub npe hu ua lub hlwb muab tau cov protein (BD-tau) biomarkers vim qhov chaw kho mob tam sim no siv los kuaj Alzheimer's kab mob ntsig txog cov kab mob neurodegenerative ntawm cov ntshav kuaj ntshav, rau Alzheimer's kab mob muaj qee yam tshwj xeeb, tab sis kuj muaj cov kua dej cerebrospinal Alzheimer neurodegenerative kab mob biomarkers muaj qhov zoo. kev sib raug zoo.
Kev kuaj mob ntawm Alzheimer's disease tam sim no xav tau kev kuaj mob neuroimaging, thiab cov kev ntsuam xyuas no kim heev thiab feem ntau siv sijhawm ntev los ua, thiab txawm tias nyob hauv Tebchaws Meskas, ntau tus neeg mob tsis muaj sijhawm los siv MRI thiab PET scans, thiab kev nkag tau ntawm cov no. Cov tswv yim duab yog qhov teeb meem loj, tus kws tshawb fawb Thomas Karikari tau hais. Yog li ntawd, txhawm rau txheeb xyuas tus kab mob Alzheimer's, cov kws tshawb fawb soj ntsuam tau siv cov lus qhia tsim los ntawm National Institute on Aging thiab Alzheimer's Disease Association hauv 2011. Cov lus qhia, hu ua AT (N) lub moj khaum, xav kom kuaj peb qhov sib txawv ntawm Alzheimer's kab mob pathology, muaj cov amyloid plaques, lub xub ntiag ntawm tau tangles, thiab neurodegenerative lesions nyob rau hauv lub hlwb, los ntawm kev ntsuam xyuas los yog kev soj ntsuam ntawm cerebrospinal kua kuaj los ntawm tus neeg mob lub cev.
Hmoov tsis zoo, cov txheej txheem no muaj qee qhov kev txwv nyiaj txiag thiab siv tau, hais kom cov kws tshawb fawb los tsim kev yooj yim thiab txhim khu kev qha AT (N) biomarker kuaj rau cov ntshav kuaj uas tuaj yeem sau cov ntshav kuaj nrog qhov tsawg kawg invasive txhais tau tias thiab xav tau cov ntaub ntawv me me. Cov kws tshawb fawb qhia tias kev tsim cov cuab yeej yooj yim los kuaj pom cov tsos mob ntawm Alzheimer's kab mob hauv cov ntshav yam tsis muaj kev cuam tshuam rau qhov zoo yuav yog ib kauj ruam tseem ceeb rau kev txhim kho kev siv thev naus laus zis. Qhov tseem ceeb tshaj plaws ntawm kev siv cov ntshav biomarkers yog ua kom tib neeg nyob zoo thiab txhim kho kev ntseeg siab thiab kev pheej hmoo ntawm Alzheimer's kuaj mob, tus kws tshawb fawb Karikari hais.
Txoj kev kuaj ntshav tam sim no tuaj yeem kuaj pom amyloid hauv plasma thiab qhov txawv txav hauv daim ntawv ntawm tau protein, uas tuaj yeem ua tiav kev kuaj mob Alzheimer's ob ntawm peb qhov kev kuaj xyuas tsim nyog, tab sis AT (N) lub moj khaum siv rau cov ntshav kuaj qhov teeb meem loj tshaj plaws yog cov kws tshawb fawb. Nws yog ib qho nyuaj rau kev txheeb xyuas rau lub hlwb tshwj xeeb cov cim neurodegeneration, tab sis kuj tsis cuam tshuam los ntawm lub cev ntawm lwm yam ua rau muaj kuab paug. Piv txwv li, cov qib ntawm neurocellulose (cov cim protein ntawm cov hlab ntsha puas tsuaj) nce hauv Alzheimer's disease, Parkinson's disease thiab lwm yam dementia, ua rau cov kws tshawb fawb tsis tshua muaj txiaj ntsig thaum sim paub qhov txawv ntawm Alzheimer's kab mob thiab lwm yam kab mob neurodegenerative; Hauv qhov sib piv, kev sim tag nrho cov ntshav tau tsis tshua muaj txiaj ntsig ntau dua li kev soj ntsuam nws cov qib hauv cov kua cerebrospinal.
Los ntawm kev siv molecular biology thiab biochemistry rau tau hauv cov ntaub so ntswg sib txawv (xws li lub hlwb), cov kws tshawb fawb tau tsim cov txheej txheem tshwj xeeb uas xaiv kuaj pom BD-tau, thaum tseem zam cov dawb-floating "loj tau" protein uas tsim los ntawm cov hlwb tsis xav txog hauv hlwb. Ua li no, cov kws tshawb fawb tau tsim cov tshuaj tiv thaiv tshwj xeeb uas xaiv khi BD-tau, ua kom yooj yim rau kev kuaj pom hauv cov ntshav. Tom qab ntawd lawv kuj tau lees paub lawv qhov kev sim siab nrog ntau dua 600 tus neeg mob los ntawm tsib pawg kev tshawb fawb ywj pheej, suav nrog cov neeg mob Alzheimer's kab mob tom qab tuag thiab cov neeg mob Alzheimer's thaum ntxov nrog kev nco tsis txaus. Cov txiaj ntsig tau pom tias qib BD-tau hauv cov ntshav kuaj ntshav ntawm Alzheimer's tus kab mob tuaj yeem ua tau raws li qib ntawm tau hauv CSF thiab paub qhov txawv Alzheimer's kab mob los ntawm lwm yam kab mob neurodegenerative. Qib ntawm BD-tau kuj tseem cuam tshuam nrog qhov hnyav ntawm amyloid plaques thiab tau tangles nyob rau hauv lub hlwb cov ntaub so ntswg paub tseeb los ntawm kev tsom xam ntawm lub hlwb anatomy. Cov neeg tshawb nrhiav cia siab tias kev kuaj ntshav hauv BD-tau yuav pab txhim kho kev tsim cov kev sim tshuaj ntsuam xyuas thiab ua kom yooj yim rau kev tshuaj xyuas thiab nrhiav cov neeg uas tsis muaj keeb kwm suav nrog hauv pawg kawm.
Raws li Karikari, muaj ntau haiv neeg ntawm kev tshawb fawb xav tau hauv kev tshawb fawb soj ntsuam, tsis yog raws li cov xim ntawm daim tawv nqaij, tab sis kuj tsim cov tshuaj zoo dua, kev sim tshuaj yuav tsum nrhiav neeg los ntawm ntau haiv neeg, tsis yog cov neeg nyob ze ntawm qhov chaw kho mob. ; Kev kuaj ntshav yog pheej yig heev, muaj kev nyab xeeb thiab tswj tau yooj yim, uas tuaj yeem txhim kho kev ntseeg siab hauv kev kuaj mob Alzheimer's disease, thiab tsis xaiv qee cov neeg koom rau kev tshawb fawb hauv kev sim tshuaj thiab tshuaj xyuas kab mob.
Tom ntej no, cov kws tshawb fawb npaj los txheeb xyuas BD-tau hauv cov ntshav ntawm qhov loj dua, suav nrog cov neeg nrhiav neeg los ntawm ntau haiv neeg thiab haiv neeg keeb kwm, los ntawm cov chaw kho mob nco, thiab cov neeg nrhiav neeg hauv zej zog. Tsis tas li ntawd, cov kev tshawb fawb no yuav suav nrog cov neeg laus uas tsis muaj pov thawj lom neeg ntawm Alzheimer's kab mob thiab nyob rau ntau theem ntawm tus kab mob. Nws yog ib qho tseem ceeb los xyuas kom meej tias cov txiaj ntsig biomarker tau txuas ntxiv mus rau cov neeg ntawm txhua qhov keeb kwm yav dhau los, thiab yuav ua rau txoj hauv kev rau kev lag luam ntawm BD-tau rau kev siv tshuaj kho mob thiab kev siv tshuaj.
Hauv kev xaus, cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tau hais tias lub hlwb tau txais los ntawm lub hlwb tuaj yeem nthuav tawm lub peev xwm los ua kom tiav AT (N) cov tswv yim hauv cov ntshav, uas yav tom ntej yuav ua rau muaj kev ntsuam xyuas ntawm Alzheimer's disease-dependent neurodegenerative txheej txheem rau kev kho mob thiab kev tshawb fawb. .
