Opioids yog tus qauv rau kev ua xua; Txawm li cas los xij, lawv cov teebmeem ntawm kev ua haujlwm plab hnyuv yog qhov tsis zoo kawm. Qhov tshwm sim ntau dua ntawm kev mob plab hauv cov neeg siv tshuaj opioid ua rau muaj kev mus pw hauv tsev kho mob ntau ntxiv. Kev tswj kev mob yog ib qho kev sib tw tseem ceeb thoob ntiaj teb. Opioids yog cov tshuaj tua kab mob zoo tshaj plaws rau kev mob qog noj ntshav thiab mob tom qab phais thiab tseem tau siv ntau ntxiv hauv cov kab mob uas tsis yog mob qog noj ntshav.
Txawm hais tias morphine yog cov tshuaj tseem ceeb rau kev kho mob, kev siv morphine kuj ua rau muaj kev cuam tshuam tsis zoo, xws li xeev siab, ntuav, thiab txo cov plab hnyuv, hu ua opioid-induced plab hnyuv tsis ua haujlwm (OBD). Txo kev thauj mus los hauv plab ua rau mob plab thiab idiopathic cem quav, uas ua rau cov kab mob esophageal reflux. Txawm tias cov koob tshuaj ntawm opioid analgesics tuaj yeem ua rau muaj kev phom sij rau plab hnyuv.
Tsis ntev los no, cov kws tshawb fawb los ntawm University of Miami tab tom ua haujlwm ntawm Br J Pharmacol. Cov kab lus hu ua "Morphine siv induces gastric microbial dysbiosis tsav gastric o los ntawm TLR2 signaling uas yog attenuated los ntawm proton twj tso kua mis inhibition", Txoj kev tshawb no teev morphine-induced gastric acid raws li ib tug tsav tsheb ntawm gastric biological dysbiosis thiab pathology, thiab qhia siv PPI raws li ib tug pheej yig. Txoj kev mus rau kev kho mob ntawm morphine-txog pathophysiology.
Hauv txoj kev tshawb no, cov neeg tshawb xyuas tau tshawb xyuas qhov cuam tshuam ntawm kev siv morphine ntawm kev mob plab hnyuv thiab nws cov txheej txheem hauv qab. Cov txiaj ntsig kho mob ntawm proton twj tso kua mis inhibition hauv kev kov yeej morphine-mediated gastric o tau tshawb xyuas ntxiv. Cov kws tshawb nrhiav tau cog 25 mg ntawm qeeb-tso morphine thiab placebo micropills hauv cov nas. Kev soj ntsuam plab hnyuv microbiome tau ua. Kev kuaj mob plab hnyuv hauv nas. Tus nqi pH hauv plab tau txiav txim siab. kab mob tsis muaj kab mob thiab TLR2KO nas tau siv los tshawb xyuas cov txheej txheem ntawm kev ua. Cov kev tshawb fawb tiv thaiv plab tau ua los ntawm kev siv cov tshuaj proton twj tso kua mis inhibitor (PPI) omeprazole.
Kev kho mob morphine ntev hloov cov kab mob hauv plab thiab ua rau muaj kev nyiam nthuav dav ntawm cov zej zog pathogenic xws li Streptococcus thiab Pseudomonas sp. Morphine ua rau muaj kev cuam tshuam ntawm lub plab mucosal txheej, nce apoptosis, thiab nce inflammatory cytokines. Tsis tas li ntawd, hauv cov nas uas tsis muaj kab mob, cov kab mob morphine-induced gastric raug txo qis, thiab kev tsim kho ntawm morphine gastric microbiota hauv cov nas tsis muaj kab mob ua rau mob plab.
Tsis tas li ntawd, morphine-mediated gastric o kuj tau txo qis hauv TLR2KO nas. Morphine ua rau poob ntawm pH hauv plab, uas ua rau muaj kab mob lom thiab mob plab. Kev kho Omeprazole inhibits gastric acid, txuag cov metabolism hauv plab, thiab tiv thaiv kev mob.