Cov poj niam kuaj mob qog noj ntshav ntawm zes qe menyuam yuav pib teb zoo rau kev kho mob, tab sis feem ntau ntawm lawv sai sai no tiv thaiv kev kho mob thiab thaum kawg tuag los ntawm tus kab mob. Tsis ntev los no, ib tsab xov xwm luam tawm nyob rau hauv lub thoob ntiaj teb phau ntawv journal Advanced Science hu ua "Nanoparticle Targeting nyob rau hauv Chemo-Resistant Ovarian Cancer Reveals Dual Axis ntawm Nyob rau hauv ib txoj kev tshawb no luam tawm nyob rau hauv lub thoob ntiaj teb phau ntawv journal Advanced Science hu ua "Kev Kho Mob Vulnerability Involving Cholesterol Uptake thiab Cell Redox Balance," cov kws tshawb fawb los ntawm Northwestern University thiab lwm lub tsev kawm ntawv tau tshawb pom Achilles pob taws ntawm chemo-resistant zes qe menyuam qog noj ntshav (xav tau cov roj cholesterol) thiab yuav ua li cas thiaj li siv tau los ua kom mob qog noj ntshav ntawm zes qe menyuam.
Hauv txoj kev tshawb no, cov kws tshawb nrhiav pom thawj zaug uas tshuaj tua kab mob ntawm zes qe menyuam thiab qog nqaij hlav muaj cov roj cholesterol vim kev noj ntau ntxiv, thiab tom qab ntawd lawv tau siv cov khoom siv hluavtaws nanoparticle uas tau tshwm sim los ua cov roj cholesterol-enriched nanoparticle rau cov qog nqaij hlav cancer. . Tab sis thaum cov qog nqaij hlav cancer khi rau cov nanoparticle cuav no, nws thaiv lawv qhov kev noj cov roj cholesterol, thiab ntxiv rau, cov kws tshawb fawb pom tias kev txo qis cov roj cholesterol tuaj yeem ua rau cov qog nqaij hlav cancer mus rau txoj kev tuag ntawm tes, thiab cov kev kho mob raws li qhov no. nanoparticle tej zaum yuav txo tau txoj kev loj hlob ntawm cov qog nqaij hlav zes qe menyuam los ntawm ntau dua 50 feem pua hauv tib neeg lub hlwb thiab cov qauv tsiaj.
Cov kws tshawb fawb vam tias yuav siv nanoparticle therapy los tiv thaiv cov kws khomob-resistant zes qe menyuam qog noj ntshav
Duab los ntawm: Advanced Science (2024). DOI: 10.1002/advs.202305212
Qhov no yog riam phom tshiab rau kev rhuav tshem cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm zes qe menyuam, hais tias tus kws tshawb fawb Prof. C. Shad Thaxton. Nrog ntau dua 18 xyoo,000 cov poj niam tuag los ntawm kev mob qog noj ntshav zes qe menyuam hauv Tebchaws Meskas txhua xyoo, nrhiav txoj hauv kev los tawm tsam cov tshuaj tiv thaiv kab mob qog noj ntshav yog qhov tseem ceeb tshwj xeeb. Txoj kev cell tuag tom qab kho nrog cov nanoparticles yog cell tuag los ntawm lipid oxidation nyob rau hauv lub cell membrane. Cov hlwb no tuaj yeem txhim kho qee qhov kev zam rau hom kev tuag ntawm tes (apoptosis), uas yog vim li cas kws khomob tsis tuaj yeem tua lawv.
Cov kev tshawb pom hauv daim ntawv no ntawm kev mob qog noj ntshav ntawm zes qe menyuam yog raws li cov kws tshawb fawb ua haujlwm ua ntej siv nanoparticles los kho tib neeg lymphomas; thiab cov txiaj ntsig ntawm daim ntawv no qhia tias txoj hauv kev no kuj tseem tuaj yeem ua tau zoo hauv kev kho mob qog noj ntshav ntawm zes qe menyuam. Tam sim no cov kws tshawb fawb, Matei thiab cov npoj yaig, tau sim cov nanoparticles hauv cov qog nqaij hlav qog nqaij hlav ntawm zes qe menyuam thiab hauv xenograft tsiaj qauv nqa cov kws khomob-resistant zes qe menyuam qog noj ntshav, cov kauj ruam tom ntej yuav yog los kuaj cov tshuaj kho tau zoo ntawm cov nanoparticles ua ke nrog cov tshuaj siv tshuaj thiab tshuaj xyuas. cov nyhuv ntawm nanoparticles ntawm lub cev tiv thaiv kab mob tiv thaiv kab mob cancer.
