Ntshav qab zib cuam tshuam ntau dua 400 lab tus tib neeg thoob ntiaj teb thiab yog lub nra hnyav rau pej xeem kev noj qab haus huv. Cov neeg mob ntshav qab zib tsim cov tshuaj insulin tsawg lossis tsis muaj, ua rau nws nyuaj rau lawv tswj lawv cov ntshav qab zib. Nws tau ntau tshaj 100 xyoo txij li thaum insulin tau siv thawj zaug hauv kev kho mob ntshav qab zib hauv xyoo 1922, tab sis insulin tsis yooj yim rau kev tswj qhov ncauj thiab yuav tsum tau txhaj tshuaj lossis lub twj tso kua mis. Cov neeg mob ntshav qab zib yuav xav tau ntau yam tshuaj insulin txhua hnub, thiab kev txhaj tshuaj ntau zaus ua rau mob ntxiv rau tus neeg mob.
Tsis tas li ntawd, kev txhaj tshuaj insulin hnyav tuaj yeem ua rau tsis ua raws li kev ua raws li cov ntaub so ntswg, thiab muaj kev pheej hmoo ntawm hypoglycemia, uas yuav ua rau lub hlwb puas, qaug dab peg, tsis nco qab, thiab txawm tuag. Yog li ntawd, peb xav tau ib txoj hauv kev yooj yim thiab siv tau zoo rau kev tswj cov tshuaj insulin.
Qhov ncauj insulin yog txoj hauv kev zoo tshaj plaws, tab sis nws yog decomposed los ntawm ib puag ncig hnyav hauv plab ua ntej nws nkag mus rau hauv plab thiab nkag mus rau cov ntshav. Tsis tas li ntawd, insulin yog ib qho macromolecule lom, thiab cov kab mob plab hnyuv tsim los ntawm cov cell epithelial nruj thiab cov mucus txheej tseem cuam tshuam ntxiv kev nqus ntawm insulin.
Tsis ntev los no, Tu Yingfeng pab neeg los ntawm Southern Medical University, ua ke nrog Peng Fei los ntawm Sun Yat-sen University, tau luam tawm cov ntaub ntawv tshawb fawb muaj npe: Micromotor Based Mini-Tablet rau qhov ncauj xa ntawm Insulin hauv ACS Nano phau ntawv journal.
Txoj kev tshawb no tau tsim cov ntsiav tshuaj micromotor hauv qhov ncauj kom nquag xa cov tshuaj insulin uas tuaj yeem kov yeej qhov hnyav ntawm plab hnyuv ib puag ncig thiab mucosal barrier system, thiab magnesium-based micromotors tso tawm hydrogen airflow ntawm qhov chaw ntawm txoj hnyuv, ua rau lub sijhawm ntev ntawm kev tswj ntshav qabzib. Ntxiv mus, cov cuab yeej no tuaj yeem siv los txhim kho bioavailability ntawm lwm cov biomacromolecules thiab muaj kev siv dav.
Cov nyuv, raws li ib feem ntawm txoj hnyuv, muaj ib txheej nyias nyias, ntau xoob ntawm cov hlwb epithelial thiab mob me me. Cov kev sim yav dhau los ntawm kev tswj hwm qhov ncauj ntawm qhov ncauj, thaum tiv thaiv insulin los ntawm gastric acid nrog microcarriers lossis nanocarriers, uas tso siab rau qhov tsis txaus ntseeg ntawm cov tshuaj insulin mus rau hauv cov colonic epithelial hlwb, tsis ua haujlwm zoo.
Hauv txoj kev tshawb no, cov tshuaj insulin-loaded mini-ntsiav tshuaj tsim los ntawm pab pawg tshawb fawb muaj cov tshuaj me me "micromotors," thiab cov kev kuaj ua ntej uas pom tau tias muaj kev nyab xeeb thiab zoo ntawm cov tshuaj insulin mus rau txoj hnyuv.
Txhawm rau ua cov ntsiav tshuaj, pab pawg tau npog cov magnesium hais nrog txheej txheej ntawm cov tshuaj insulin thiab liposome. Tom qab ntawd lawv sib tov cov khoom nrog ci dej qab zib, nias rau hauv cov ntsiav tshuaj me me kwv yees li 3 hli ntev, thiab tom qab ntawd npog lawv nrog cov hmoov txhuv nplej siab esterified tAo tiv thaiv cov tshuaj los ntawm gastric acid, coj lawv mus rau txoj hnyuv.
Thaum cov ntsiav tshuaj yog decomposed nyob rau hauv txoj hnyuv, cov magnesium particles reacts nrog dej los tsim ib tug ntws ntawm hydrogen npuas, uas, zoo li micromotors, thawb insulin mus rau hauv lub colonic mucosa thiab absorbed.
Tsis ntev los no, magnesium-based micromotors tau siv dav vim tias lawv tuaj yeem tsim cov npuas hydrogen nyob rau hauv cov kua hauv lub cev hauv zos, tsim kom muaj lub zog tsav tsheb uas txhim kho kev nqus thiab nqus ntawm cov tshuaj insulin hauv txoj hnyuv, yog li txhim kho qhov ncauj bioavailability ntawm insulin, pab pawg tau hais. .
Pab neeg ntawm tus qauv nas ntshav qab zib tau kuaj cov tshuaj insulin mini hauv qhov ncauj, pom tias nws tuaj yeem txo qis cov ntshav qab zib cov nas ntshav qab zib nas, tshwm sim los ntawm cov kab mob hauv zos dej ntawm qhov nrawm nrawm ntawm magnesium-based micro lub cev muaj zog ntxiv txhim kho colonic mucosa. permeability thiab nquag xa cov tshuaj insulin, kev ruaj ntseg ntawm cov ntshav qab zib ntau tshaj 5 teev. Siv cov txheej txheem kev xa cov tshuaj insulin tshiab no, cov ntshav qabzib tuaj yeem tswj tau yuav luag qis dua li cov tshuaj insulin.
Txawm hais tias yuav tsum tau ua haujlwm ntau ntxiv, txoj kev tshawb no txo lub sijhawm ntawm kev tswj hwm cov tshuaj insulin thiab muab kev ua tau zoo dua, ua kom pom qhov ua tau ntawm cov tshuaj insulin hauv qhov ncauj thiab sawv cev rau cov kauj ruam tseem ceeb hauv kev tsim cov tshuaj txhaj tshuaj rau hauv qhov ncauj. Ntxiv mus, magnesium-based micromotors tau yooj yim kho tau thiab biodegradable rau cov ntawv cog lus hauv biomedical field.
