Mesalamine Basic Information
| Khoom npe | Mesalamine |
|
Synonyms |
5-Aminosalicylic acid, 98.5 feem pua, IKK inhibitor; 2-HYDROXY-5-AMINOBENZOIC ACID;3-Carboxy-4-hydroxyaniline;5-AMINO{{8 }}HYDROXYBENZOIC ACID;5-AMINOSALICYLIC ACID;5-ASA;5-AS;rowasa |
| CAS | 89-57-6 |
| MF | C7H7TSIS MUAJ3 |
| MW | 153.135 |
| EINECS | 201-919-1 |
Mesalamine Chemical Properties
| Melting point | 275-280 degree (dec.) (lit.) |
| Boiling point | 276.03 degree (kev kwv yees ntxhib) |
| ceev | 1.3585 (zeeg) |
| vapor siab | 0Pa ntawm 25 degree |
| Refractive Index | 1.5500 (kwv yees) |
| Fp | 279-281 degree |
| cia temp. | 2-8 degree |
| solubility | Soluble hauv dimethyl sulfoxide. |
| pka ua | 2.74, 5.84 (ntawm 25 degree) |
| daim ntawv | ntsiav tshuaj |
| xim | tawm-dawb mus rau grey |
| PH | 4. 0-4.1 (0.8g/l, H2O, 20 degree) |
| PH Range | Tsis yog-B uorescence (3.1) rau lub teeb ntsuab B uorescence (4.4) |
| Dej Solubility | <0.1 g/100 mL at 21 ºC |
| Decomposition | 279-281 ºC |
| Merck | 14,5904 |
Mesalamine Siv thiab Synthesis
|
Siv |
Antibacterials rau kev kho mob tuberculosis. Feem ntau yog siv los kho tuberculosis |
|
Kev piav qhia |
5-Aminosalicylic acid (5-ASA) yog ib qho tshuaj metabolite thiab muaj peev xwm ua haujlwm pharmacologically ntawm sulphasalazine, cov tshuaj siv los kho Crohn tus kab mob thiab cov kab mob ulcerative. Txawm li cas los xij, cov txheej txheem uas cov tshuaj no ua haujlwm tsis tau tsim. Hauv kev ntsuam xyuas ntshav tag nrho, 5-ASA ua pov thawj tias tsis muaj zog, tsis muaj kev xaiv inhibitor ntawm COX-1 thiab COX-2 nrog IC50tus nqi ntawm 410 thiab 61 μM, feem. Hauv ionophore-stimulated colonic mucosal hlwb, 1 mM 5-ASA tsis inhibit prostaglandin E2(PGE2) ntau lawm, tab sis txo leukotriene B4(LTB4) synthesis approx. 50 feem pua. Hauv ionophore-stimulated tib neeg leukocytes, 400 μM 5-ASA txo LTB4ntau lawm kwv yees li 20 feem pua. 5-ASA tsis inhibit 15-hydroxy PGDH ntawm qhov siab txog li 50 μM. Fisalamine yog ib qho hnyuv metabolite ntawm sulfasalazine pab tau rau hauv kev kho mob ntawm ulcerative colitis thiab rau ib tug tsawg degree ntawm kev tswj ntawm Crohn tus kab mob. Kev tswj hwm raws li suppository, nws zoo nkaus li tsis muaj qhov tsis txaus siab-hom kev phiv ntawm sulfasalazine. |
|
Chemical Properties |
Dawb rau Off-White hmoov |
Cim npe nrov: mesalazine cas no.89-57-6, Suav teb, manufacturers, lwm tus neeg, Hoobkas, kev cai, wholesale
