Ceftriaxone sodium Basic cov ntaub ntawv
|
Khoom npe: |
Ceftriaxone sodium |
|
Synonyms: |
CEFATRIAXONE;2,5,6-tetrahydro-2-methyl-5,6-dioxo-)(methoxyimino)acetyl)amino)-8-oxo-3- (((;4-triazin{{10}}yl)thio)methyl)-,sodiumsalt,hydrate(2:4:7)(6r-(6-alpha,{ {18}};5-Thia{{20}}azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[( 2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-} }methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium ntsev, [6R-[6 , 7 (Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z) -(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro{{ 66}}methyl-5,6-dioxo-1,2,4-triazin-3-}yl)thio]methyl]-, disodium ntsev, (6R,7R ) -; Ceftriaxone disodium; Longaceph; Ceftriaxonesodiumnon-steriled |
|
CAS: |
74578-69-1 |
|
MF: |
C18H16N8Na2O7S3 |
|
MW: |
578.57 |
|
EINECS: |
277-930-0 |
Ceftriaxone sodium Chemical Properties
| cia temp. | 4 degree, tiv thaiv lub teeb |
| Dej Solubility | Dej: Ntau dua lossis sib npaug li 40 mg / mL (66.60 mM) |
Ceftriaxone sodium Siv thiab Synthesis
| Kev piav qhia | Ceftriaxone yog ib qho cephalosporin (SEF ib qho tsis tshua muaj spor nyob rau hauv) tshuaj tua kab mob uas yog siv los kho tej yam mob xws li kab mob ua pa qis, kab mob ntawm daim tawv nqaij thiab daim tawv nqaij, kab mob urinary, kab mob pelvic inflammatory, kab mob septicemia, pob txha thiab pob qij txha kab mob, thiab meningitis. |
| Keeb kwm | Rocephin, Roche, Switz., 1982 |
| Siv | Ceftriaxone sodium yog tshuaj tua kab mob, ib qho impurity ntawm Ceftriaxone (C244995). Nws yog ib qho tshuaj tua kab mob, ib tiam thib peb cephalosporin. |
| Hom lub npe | Rocephin (Roche). |
| Kev kho mob muaj nuj nqi | Tshuaj tua kab mob |
| Veterinary tshuaj thiab kev kho mob | Ceftriaxone yog siv los kho cov kab mob loj, tshwj xeeb tshaj yog tiv thaiv cov kab mob Enterobacteriaceae uas tsis raug rau lwm cov tshuaj uas tsis tshua muaj nqi lossis thaum aminoglycosides tsis qhia (vim lawv muaj peev xwm toxicity). Nws lub neej ntev ib nrab, kev nkag mus rau CNS zoo, thiab kev ua haujlwm tawm tsam Borrelia burgdorferi kuj tau ua rau nws muaj peev xwm xaiv los kho tus kab mob Lyme. |
Ceftriaxone sodium Specification
|
Kev piav qhia |
Dawb mus rau yellowish-txiv kab ntxwv crystalline hmoov |
|
Kev txheeb xyuas |
|
|
|
|
|
|
Solubility |
Dawb soluble nyob rau hauv dej, sparingly soluble nyob rau hauv |
|
Crystallinity |
Nws qhia txog birefringence thiab extinction txoj haujlwm. |
|
pH |
6.0-8.0 |
|
Dej |
8.0%-11.0% |
|
Organic impurities |
Deacetylcefotaxime lactone Tsawg dua lossis sib npaug rau 0.5% |
|
{{0}}Aminocephalosporanic acid Tsawg dua lossis sib npaug li 0.5% |
|
|
Ceftriaxone triazine analog Less dua los yog sib npaug rau 1.0% |
|
|
Ceftriaxone benzothiazolyl oxime Tsawg dua lossis sib npaug rau 0.2% |
|
|
Deacyl ceftriaxone Tsawg dua los yog sib npaug rau 0.5% |
|
|
Ceftriaxone {{0}}ene isomer Tsawg dua lossis sib npaug li 0.3% |
|
|
Ceftriaxone E-isomer Tsawg dua lossis sib npaug rau 0.5% |
|
|
Ib tus neeg twg uas tsis tau teev meej impurity Tsawg dua lossis sib npaug rau 0.2% |
|
|
Tag nrho impurity? Tsawg dua lossis sib npaug li 2.5% |
|
|
Tsis muaj menyuam |
Raws li cov specifications |
|
Cov kab mob endotoxins |
＜0.20EU/mg |
|
Qhov tshwm sim ntawm kev daws teeb meem |
Qhov kev daws teeb meem yog qhov tseeb thiab tsis mob siab rau ntau |
|
Piculate teeb meem |
Ntau dua lossis sib npaug li 10µm:? Tsawg dua lossis sib npaug li 6000pc / g |
|
Ntau dua lossis sib npaug rau 25µm: Tsawg dua lossis sib npaug rau 600pc / g |
|
|
Residue kuab tshuaj |
Acetone Tsawg dua lossis sib npaug li ?5000ppm |
|
Qhov ntom ntom |
Cov khoom siv |
|
Tapped ntom |
Cov khoom siv |
|
Absorbance ntawm 430nm |
Cov khoom siv |
|
Flow Index |
Cov khoom siv |
|
Assay |
Nws muaj qhov sib npaug ntawm NLT 795µg / mg |
Cim npe nrov: Ceftriaxone sodium, sterile cas no.74578-69-1, Tuam Tshoj, tuam ntxhab, lwm tus muag khoom, Hoobkas, kev cai, lag luam wholesale
