Olaparib Cov ncauj lus yooj yim
Khoom npe: | Olaparib |
Txhais: | 1- (Cyclopropylcarbonyl) -4- [5 - [(3,4-dihydro-4-oxo-1-phthalazinyl) Methyl] -2-fluorobenzoyl] piperazin; 4 - [[3 - [[4- (Cyclopropylcarbonyl) - 1-piperazinyl] carbonyl] -4-fluorophenyl] Methyl] -1 (2H) -phthalazinone |
CAS: | 763113-22-0 |
MF: | C24H23FN4O3 |
MW: | 434.46 |
EINECS: | 642-941-5 |
Olaparib Lub Cev thiab Tshuaj Zog
Melting taw tes | Tsis muaj |
Boiling taw tes | Tsis muaj |
Kev Mob Cia | Tsis muaj |
| Flash Point | Tsis muaj |
Daim Ntawv | Hmoov dawb dawb |
Tub sab | Tsis muaj |
OlaparibKev pab
Kev Siv | Siv los kho cov hlav BRCA-mutated |
Olapanib yog qhov ncauj tshiab polyadenosine polyphosphate ribose polymerase [PARP] inhibitor. PARP suav nrog cov tswv cuab tseem ceeb tshaj plaws ntawm peb tsev neeg muaj protein: PARP1, PARP2 thiab PARP3. PARP cov enzymes tau koom nrog hauv tsev cellostasis ib txwm, xws li DNA hloov tsheb, kev tswj lub voj voog ntawm tes thiab kev kho DNA. Cov txiaj ntsig ntawm olaparib hauv vitro kuaj pom tias kev kho mob monotherapy lossis platinum-tshuaj cov tshuaj tua kab mob pom tias kev txwv tsis pub muaj kev loj hlob ntawm kev xaiv cov qog ntawm cov kab mob thiab txo cov qog nce nyob hauv nas xenograft cov qauv ntawm tib neeg mob cancer. Tom qab kho nrog olaparib, cytotoxicity thiab kev tiv thaiv qog ua haujlwm ntawm cov qog cov qauv xovtooj ntawm cov kab mob hauv BRCA-cov tsis muaj cov nas uas muaj cov kabmob kheesxaws tau nce ntxiv. Hauv kev tshawb nrhiav hauv vitro kuj tau qhia tias cov cytotoxicity ntxias los ntawm olaparib yuav cuam tshuam nrog kev cuam tshuam ntawm PARP kev ua haujlwm enzyme thiab qhov nce ntawm PARP-DNA ua tsim, uas ua rau muaj kev puas tsuaj ntawm cell homeostasis thiab cell tuag.
Cim npe nrov: olaparib cas no.763113-22-0, Suav teb, manufacturers, lwm tus neeg, hoobkas, Mekas, lag luam wholesale
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