Erlotinib hydrochloride Cov ntaub ntawv yooj yim
|
Khoom npe: |
Erlotinib hydrochloride |
|
Synonyms: |
ERLOTINIB HCL;ERLOTINIB HCL SALT;ERLOTINIB HCL ntsev: TARCEVA; Erlotinib, Hydrochloride Salt; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy){{ 5}}quinazolinamine, Hydrochloride ntsev, OSI 774, Tarceva; N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine;[6,{16}}Bis- (2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine; Tarceva Hydrochloride Saib E625000 |
|
CAS Nr: |
183319-69-9 |
|
MF: |
C22H24ClN3O4 |
|
MW: |
429.9 |
|
EINECS: |
620-491-0 |
Erlotinib Hydrochloride Cov Khoom Siv Tshuaj
| Melting point | 223-225 degree |
| Boiling point | 553.6ºC ntawm 760 mmHg |
| cia temp. | Inert cua, Khaws hauv lub freezer, hauv qab -20 degree |
| solubility | Soluble hauv DMSO (txog 18 mg / ml nrog sov). |
| pka ua | pKa (25 degree): 5.42 |
| daim ntawv | Cov hmoov daj. |
| xim | Dawb los yog dawb dawb |
| Kev ruaj ntseg: | ruaj khov rau 1 xyoo txij li hnub ntawm kev yuav khoom raws li muab. Cov kev daws teeb meem hauv DMSO tuaj yeem khaws cia ntawm -20 degree mus txog 3 lub hlis. |
Erlotinib hydrochloride Siv thiab Synthesis
| Chemical Properties | Off-White Solid |
| Keeb kwm | Pfizer (USA) |
| Siv | Erlotinib hydrochloride (V), ib qho quinazoline muab tau los ntawm me me molecule inhibitor ntawm epidermal growth factor receptor (EDGFR) tyrosine kinase, tau pom zoo nyob rau lub Kaum Ib Hlis, 2004, rau kev kho mob ntawm kev mob qog noj ntshav siab lossis metastatic non-smallcell ntsws cancer. Nws belongs rau tib chav kawm li gefitinib, lwm yam quinazoline tau pom zoo rau kev kho mob qog noj ntshav siab, tab sis nrog kev txhim kho cov tshuaj pharmacokinetic. Lub molecule tau pib los ntawm Pfizer thiab kev txhim kho pib hauv kev koom tes nrog OSI, uas suav tias muaj cai tag nrho rau cov tshuaj thaum Pfizer koom nrog Warner Lambert. Tom qab ntawd, Genentech / Roche tau mus rau hauv daim ntawv cog lus nrog OSI los tsim thiab ua lag luam cov tshuaj hauv Asmeskas thiab thoob ntiaj teb. |
Nws yog hydrochloride ntawm molecularly tsom tshuaj erlotinib. US Food and Drug Administration (FDA) tau pom zoo erlotinib (Tarceva) ua ke nrog gemcitabine ua thawj kab kev kho mob rau cov mob qog noj ntshav hauv zos thiab metastatic pancreatic. Lub me me molecule compound erlotinib yog receptor tyrosine kinase inhibitor. Nws inhibits cov tshuaj tiv thaiv phosphorylation los ntawm kev sib tw nrog adenosine triphosphate mus rau qhov chaw catalytic ntawm receptor tyrosine kinase hauv lub xovtooj ntawm tes, yog li thaiv qhov Nws muaj cov teeb liab hloov pauv, inhibits cov haujlwm ntawm qog cell ligand-dependent HER-1/EGFR , thiab ua tiav cov nyhuv ntawm inhibiting qog cell proliferation. Nws kuj yog lwm tyrosine kinase inhibitor siv los kho NSCLC.
Cim npe nrov: erlotinib hydrochloride cas no.183319-69-9, Suav teb, manufacturers, lwm tus neeg, Hoobkas, kev cai, wholesale
![2-[(6-Chloro-3,4-dihydro-3-methyl{5}},4-dioxo- 1(2H )-pyrimidinyl)methyl] -4-fluorine Cayanobenzene CAS NO.{11}}](/uploads/202024095/small/2-6-chloro-3-4-dihydro-3-methyl-2-4-dioxo-127233995734.jpg)
