Aspirin CAS NO.50-78-2

Cov tshuaj aspirin Cov ncauj lus

Tshuaj aspirin Lub Cev thiab Tshuaj Zog

Tshuaj aspirinKev pab

[Pharmacological action] Acetylsalicylic acid yog tshuaj ntsuab antipyretic thiab analgesic, thiab nws kuj muaj cov nyhuv ntawm kev tawm tsam platelet sib xyaw. Acetylsalicylic acid muaj antithrombotic cov yam ntxwv hauv lub cev thiab tuaj yeem txo qhov tsim ntawm qhov muaj mob txhaws nyob hauv cov hlab ntshav puag ncig. Txwv tsis pub tshaj tawm cov lus teb ntawm platelets thiab kev tso tawm ntawm endogenous ADP, 5-HT, thiab lwm yam Yog li ntawd, qhov kev sib cais thib ob ntawm platelets yog inhibited tab sis thawj theem kev sib cais tsis yog tshuaj tiv thaiv. Lub tshuab ntawm acetylsalicylic acid yog rau acetylate cyclooxygenase ntawm platelets, yog li inhibiting qhov tsim ntawm peroxide hauv lub nplhaib, thiab kev tsim ntawm TXA2 Chembook kuj raug txo. Nws tseem tuaj yeem ua cov acetylate platelet membrane cov nqaijrog thiab inhibit platelet membrane enzymes, uas kuj pab tau ua kom cov platelet muaj nuj nqi. Vim tias cyclooxygenase raug txwv, nws cuam tshuam cov synthesis ntawm PGI2 hauv cov hlab ntsha phab ntsa; cov enzyme uas tseem tuaj yeem ua rau lub zog ntawm cov platelet TXA2, xws li cov koob tshuaj siab, yuav cuam tshuam rau kev tsim TXA2 thiab PGI2. Nws yog qhov tsim nyog rau ischemic mob plawv. Tom qab cov hlab ntsha o hla kev phais (PTCA), nws tuaj yeem tiv thaiv kev hloov hlab hlwb ischemia, mob stroke, thiab myocardial infarction, thiab txo qhov tshwm sim ntawm arrhythmia.