Enzalutamide Cov ncauj lus yooj yim
Khoom npe: | Enzalutamide |
Txhais: | MDV 3100; XTANDI; UNII-93T0T9GKNU; [14C] -Enzalutamide; N-methyl-4- [3- (4-cyano-3-trifluoromethylphenyl) -5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1- yl] -2-fluorobenzamide; 4- (3- (4-cyano-3- (trifluoromethyl) phenyl) -5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl) -2-fluoro-N- methylbenzamide |
CAS: | 915087-33-1 |
MF: | C21H16F4N4O2S |
MW: | 464.44 |
EINECS: | 805-022-1 |
Enzalutamide Cov Khoom Siv Lub Cev thiab Tshuaj Lom
Melting taw tes | Tsis muaj |
Boiling taw tes | Tsis muaj |
Kev Mob Cia | Tsis muaj |
| Flash Point | Tsis muaj |
Daim Ntawv | Tsis muaj |
Tub sab | Tsis muaj |
EnzalutamideKev pab
Kev Siv | Siv los kho tus txiv neej castration-resistant prostate siab heev uas tau kis lossis rov muaj dua. |
Enzalutamide yog ib qho androgen receptor inhibitor. Nws lub hom phiaj yog txawv los ntawm cabazitaxel thiab abiraterone. Nws muaj peev xwm sib tw khi qhov khi ntawm androgen rau cov txais thiab inhibit nuclear thauj ntawm androgen receptor. Raws li kev sib cuam tshuam ntawm cov receptor thiab DNA, hauv kev tshawb nrhiav hauv vitro tau qhia tias enzalutamide tuaj yeem thaiv txoj kev loj hlob ntawm prostate mob hlwb thiab ua rau lawv tuag. Enzalutamide tuaj yeem txo cov qog loj hauv nas prostate cancer xenograft qauv kev sim ua kom tiav Lub ntsiab metabolite ntawm enzalutamide yog N-desmethyl enzalutamide, uas qhia tau zoo ib yam li kev tiv thaiv kom enzalutamide hauv vitro. Qhov pom zoo ntawm cov neeg laus pom zoo ntawm cov tshuaj yog 160 mg rau ib hnub. Nws yog sai sai tom qab noj cov tshuaj. Qhov siab nce mus txog qhov siab tshaj plaws hauv 0.5 ～ 3h, qhov nruab nrab lub davhlau ya nyob nruab nrab yog 5.8d, thiab cov enzymes metabolizing lub ntsiab yog CYP2C8 thiab CYP3A4. Cov tshuaj yuav tsum raug zam nyob rau hauv kev sib xyaw nrog cov muaj zog CYP2C8 inhibitors (xws li gemfibrozil, gemfibrozil), thiab cov neeg tswj hwm yog tias tsim nyog, cov tshuaj ntawm enzalutamide yuav tsum raug txo mus rau 80mg, ib zaug ib hnub.
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