Cov plaub hau poob yog ib qho teeb meem pos uas feem ntau ua rau cov neeg muaj hnub nyoog nruab nrab, tshwj xeeb tshaj yog cov txiv neej hnub nyoog nruab nrab, thiab qhov tshwm sim ntawm kev hloov cov plaub hau thiab wig kev lag luam yog booming. Raws li cov ntaub ntawv tshaj tawm los ntawm National Health Commission, ntau dua 250 lab tus tib neeg hauv Suav teb raug kev txom nyem los ntawm cov plaub hau poob. Qhov nruab nrab, ib ntawm txhua tus neeg muaj plaub hau poob. Ntxiv mus, qhov kev faib ua feem ntawm cov plaub hau poob ntawm "post-90s" yog siab li 84 feem pua, 20 xyoo dhau los ntawm cov tiam dhau los, thiab cov qauv ntawm cov hnub nyoog qis yog pom tseeb.
Cov plaub hau poob feem ntau suav nrog androgenic alopecia (AGA) thiab alopecia areata (AA). Ntawm lawv, androgenic alopecia (AGA) yog ib qho kab mob uas tau txiav txim siab los ntawm cov lus teb ntau dhau rau androgens, uas yog tus cwj pwm los ntawm cov plaub hau luv luv ntawm cov tawv taub hau tom qab kev laus, suav txog li 90 feem pua ntawm tag nrho cov plaub hau poob. Tam sim no, cov tshuaj pom zoo los kho AGA alopecia yog txwv, tsuas yog minoxidil thiab finasteride.
Alopecia areata (AA) yog kab mob autoimmune uas tuaj yeem ua rau cov quav hniav zoo li cov plaub hau poob ntawm tawv taub hau, ntsej muag thiab qee zaum lwm qhov ntawm lub cev. Alopecia areata feem ntau tshwm sim thawj zaug hauv menyuam yaus, thiab thawj qhov xwm txheej txawv ntawm tus neeg mob mus rau tus neeg mob. Alopecia areata tuaj yeem tshwm sim hauv txhua lub hnub nyoog, poj niam txiv neej thiab haiv neeg. Kev tshawb fawb txog kab mob kis tau pom tias qhov muaj feem ntau ntawm AA hauv Suav teb yog 0.27 feem pua , thiab cov kev tshawb fawb txawv teb chaws qhia tau hais tias lub neej ntawm AA yog li 2 feem pua.
Baricitinib yog ib qho JAK inhibitor muab tshuaj noj ib hnub ib zaug. Nws tau raug pom zoo nyob hauv ntau dua 70 lub teb chaws thiab cheeb tsam thoob plaws ntiaj teb los kho cov neeg laus cov neeg laus uas muaj mob hnyav rau mob rheumatoid mob caj dab (RA). Cov kev pom zoo hauv Suav teb muaj feem xyuam rau cov neeg laus cov neeg laus uas muaj mob rheumatoid mob caj dab uas muaj kev ua haujlwm tsis zoo lossis kev tsis haum rau ib lossis ntau dua cov tshuaj tiv thaiv rheumatic (DMARD). Barretinib tuaj yeem siv ua ke nrog methotrexate lossis lwm yam tshuaj tua kab mob rheumatic los txhim kho tus mob.
Nyob rau lub Kaum Ob Hlis 2009, Lilly kws tshuaj thiab Incyte tshaj tawm lub ntiaj teb no tshwj xeeb patent thiab kev koom tes daim ntawv cog lus rau R & D, kev lag luam thiab lwm yam kev sib txuas ntxiv ntawm barretinib tiv thaiv kab mob inflammatory thiab kab mob autoimmune.
Pharnexcloud.com com; Kev ua tau zoo thoob ntiaj teb ntawm cov khoom no hauv xyoo tas los
Thaum Lub Kaum Hli, 2021, Lilly thiab Incyte tau tshaj tawm cov txiaj ntsig ntawm ob theem III kev sim tshuaj ntsuam xyuas siab tawv-aa1 thiab siab tawv-aa2 ua rau 1200 tus neeg mob uas muaj alopecia areata hnyav, uas yog theem loj tshaj plaws III qhov kev tshawb fawb soj ntsuam uas tau ua tiav thawj qhov kawg. Qhov hnyav alopecia areata tau txhais tias yog alopecia areata nrog cov cuab yeej alopecia hnyav (ntshav) qhab nia Ntau dua lossis sib npaug rau 50 (scalp alopecia cheeb tsam Ntau dua lossis sib npaug li 50 feem pua ). Cov ntsiab lus tseem ceeb kawg yog qhov kev faib ua feem ntawm cov neeg mob uas muaj ntsev tsawg dua lossis sib npaug li 20 (piv txwv li 80 feem pua lossis ntau dua cov plaub hau npog) ntawm lub lim tiam 36. Hauv ob qho kev tshawb fawb, kwv yees li ib feem peb ntawm cov neeg mob kho nrog 4 mg ntawm baretinib ua tiav cov tawv taub hau plaub hau. ntawm ntau dua 80 feem pua (siab tawv-aa1=35.2 feem pua, siab tawv-aa2=32.5 feem pua), piv nrog 5.3 feem pua (siab tawv-aa1) thiab 2.6 feem pua (siab tawv-aa2), feem , hauv pawg placebo.
Piv nrog rau cov neeg mob noj cov placebo, ib feem peb ntawm cov neeg mob tau ua tiav kev tsim kho tshiab lossis rov tsim cov pob muag thiab cov plaub muag tom qab 36 lub lis piam ntawm kev kho mob nrog 4mg barretinib, thiab cov neeg mob no muaj qhov khoob loj lossis tsis muaj pob muag lossis cov plaub muag ntawm lub hauv paus. (brave-aa1:4mg koob tshuaj: plaub muag =31.4 feem pua [n=59]; plaub muag =33.5 feem pua [n{{10}}]; placebo : plaub muag =3.2 feem pua [n=4]; plaub muag =3.1 feem pua [n=3]; siab tawv-aa2:4mg koob tshuaj: plaub muag =34 .8 feem pua [n=56]; plaub muag =34.3 feem pua [n=48]; placebo: plaub muag =4.5 feem pua [n=5]; plaub muag =5.6 feem pua [n=5]; P Tsawg dua lossis sib npaug rau 0.001 rau txhua qhov kev sib piv nrog cov placebo). Cov plaub muag plaub muag thiab plaub muag poob yog qhov tshwm sim ntawm kev siv cov kws kho mob qhia (clinro) ntsuas rau cov plaub muag plaub muag ™ Thiab clinro ntsuas rau qhov muag lash plaub hau, ib qho cuab yeej tshiab kho mob pov thawj tsim los ntawm Lilly ™ Rau kev ntsuam xyuas.
Tib lub sijhawm, lub siab tawv-aa theem III qhov chaw kho mob kuj tau soj ntsuam qhov ua tau zoo ntawm Elomin ® Tsis muaj cov cim kev nyab xeeb tshiab tau pom. Tsawg tus neeg mob hauv txoj kev tshawb fawb tau nres kev kho mob vim yog qhov tshwm sim tsis zoo (2.6 feem pua lossis tsawg dua hauv ob qho kev tshawb fawb), thiab qhov mob hnyav ntawm cov kev kho mob feem ntau yog me me lossis nruab nrab.
Thaum Lub Rau Hli 13, 2022, FDA tau tshaj tawm tias nws tau pom zoo baricitinib rau npe rau kev kho mob ntawm cov neeg laus uas muaj mob alopecia areata, uas yog thawj txoj kev kho mob pom zoo los ntawm FDA rau kev kho mob ntawm alopecia areata. Tsis tas li ntawd, European Union tab tom yuav tau txais kev pom zoo: Human Medicinal Products Committee ntawm European kev tswj hwm tshuaj txhawb nqa nws qhov kev pom zoo ntawm barretinib rau kev kho mob ntawm cov neeg laus uas muaj mob alopecia areata. Japanese regulators tab tom tshuaj xyuas cov ntawv thov kev lag luam tshuaj tshiab.