Txuj ca
GancicLovir yog nucleoside antiviral tus neeg sawv cev uas muaj kev sib tw thiab dopes rau DNA ntawm cov kab mob thiab host hlwb, yog li inhibiting DNA synthesis. GancicLovir yog nucleoside antiviral uas inhibits DNA synthesis los ntawm kev sib tw hauv cov kab mob DNA thiab doping rau DNA ntawm tus kabmob thiab tus tswv tsev.
GancicLovir yog nucleoside antiviral tus neeg sawv cev uas muaj kev sib tw thiab dopes rau DNA ntawm cov kab mob thiab host hlwb, yog li inhibiting DNA synthesis. GancicLovir yog nucleoside antiviral uas inhibits DNA synthesis los ntawm kev sib tw hauv cov kab mob DNA thiab doping rau DNA ntawm tus kabmob thiab tus tswv tsev.
Nucleoside Antivirals
GancicLovir (GancicLovir), Yees duab paub li {}}}}}}}}}}}}} nucleoside derivative. Nws muaj qhov dav dav-spectrum, ua tau zoo heev inhibition ntawm herpes tus kab mob, thiab yog cov tshuaj tiv thaiv kab mob cytomegalover, thiab tseem muaj cov nyhuv muaj zog rau tus kab mob siab B thiab Adenovirus. Nws yog homologue of Acyclovir (ACV), thiab nws cov antiviral zoo sib xws, tab sis ntau tshaj lub zog, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj plaws, tshwj xeeb tshaj yog nyob hauv cov neeg mob AIDSGALSWIRUS hauv AIDS cov neeg mob uas muaj zog inhibitia cov nyhuv. Nws yog kev siv tshuaj kho mob kho kom raug kev soj ntsuam thiab kev kho mob ntawm cytomeGalovirus retinivitis nyob rau cov neeg mob tiv thaiv kab mob (suav nrog AIDS cov neeg mob). Nws kuj tseem siv tau rau kev tiv thaiv cytomeGalirus muaj mob hauv cov neeg hloov khoom nruab nrog cev thiab rau kev tiv thaiv cytomeGalius kab mob hauv CytomeGalovirus Deropositive Aids cov neeg mob. Cov khoom no yog qhov ua tau zoo, kev xaiv tsis muaj txiaj ntsig los ntawm Asmeskas nws yog thawj tus tshuaj uas tau pom zoo los ntawm Cytaulorovirus (CMV) tau txais kev pab tshwj xeeb txoj cai los tsim thiab ua haujlwm cov khoom.Qhov khoom tau pom zoo thawj zaug rau lub Rau Hli 1988 nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, thiab yog tom qab ntawd Pom zoo rau kev siv hauv Fabkis, Asmeskas, Nyiv, West Lub Tebchaws Yelemees, Ltalis thiab Canada. Tom qab ntawd, Fabkis, Tebchaws Asmeskas, Nyiv, Tebchaws Yelemees, Ltalis thiab Canada tseem pom zoo siv cov khoom lag luam. Txog thaum lub Rau Hli 1999, nws tau siv ntau tshaj 70 lub teb chaws thiab cov cheeb tsam rau kev tiv thaiv cytomeGalius tus neeg mob thiab cov neeg hloov chaw nruab nrog cev. Xyoo 2002, GandicLovir ntsiav tshuaj tau pom zoo los ntawm FDA hauv Suav teb, thiab tam sim no nyob ntawm kev ua lag luam.
Tus ua dej khov kho
Acyclovir yog ib lub thib ob-tiam dav hlau dav hlau tsim los ntawm glaxo zoo nkauj hauv 1981, uas tuaj yeem xaiv tus kab mob repal interication hauv cytomeGalovirus (CMV) - Cov cell kis. Txawm li cas los xij, lub drawbacks ntawm Acyclovir yog tias nws yuav ua rau muaj teeb meem kev ua haujlwm hauv HIV muaj kev kho ua ke; Hauv kev tshawb nrhiav kev coj ua, Acyclovir muaj cov antictomegaloveriraliral kev ua tau zoo thiab tuaj yeem ua rau muaj kev pom zoo ntawm cov koob tshuaj ntau. Qhov loj tshaj plaws tsis zoo yog tias nws tau coj ntau tshaj li ib txwm nyob rau ib hnub twg.
Kev siv
1. Rau kev ua raws thiab kev kho mob ntawm cytomeGalovirus retinitis nyob rau cov neeg mob tiv thaiv kab mob tsis zoo (suav nrog AIDS Cov neeg mob). 2. Rau kev tiv thaiv cytomeGalirus raug mob hauv cov neeg mob cytomepanus tus mob hauv cov neeg mob AIDS nrog cov mob cytomepalovirus serologic.
Pharmaconinetics
Tsis zoo nqus tau qhov ncauj. Bioavailability yog 5% thaum coj ntawm lub plab khoob thiab 6% rau 9% thaum noj nrog zaub mov. Lub ncov siab ntshav siab tuaj yeem ncav cuag 1 ~ 1.2mg / u nrog ib qho kua ntawm 3g, thiab 8.3 ~ thiab 8.3 ~ 1 teev). Cov khoom siv tau dav hauv lub cev hauv ntau Cov ntaub so ntswg thiab tuaj yeem hla daim ntaub thiab tseem sau cov nqaij lub qhov muag. Lub concentration hauv Cerebrospinal kua yog 24% rau 7 {14}}}}}}}}} {% ntawm cov protein khi tsawg (1% rau 2%) Cov. Ib nrab-lub neej ntawm cov tshuaj yog 2. {{{}}. 5 teev rau lub sij hawm ntawm qhov ncauj, uas tuaj yeem ntev txog {teev (rau kev sib tw Kev tswj hwm) thiab 15. {{{{{}}. 2 teev (rau kev tswj hwm qhov ncauj) feem rau cov neeg mob uas tau txo lub raum muaj nuj nqi. Cov tshuaj tsis yog metabolized nyob rau hauv lub cev thiab tau ua rau muaj feem ntau hauv nws daim ntawv ntawm ob lub raum los ntawm Hemodialysis lossis peritoneal lim ntshav.
Cov kev tawm tsam
1. Cov tshuaj tiv thaiv zoo li no yog Myelosupression, tom qab siv txog 40% ntawm cov neeg mob platelet suav txo qis dua 50,000 / hli, Ib qho ntxiv, yuav muaj anemia. Kuaj ntshav ib zaug ib lub lim tiam rau tag nrho lub sijhawm ntawm kev siv yeeb tshuaj .2. Central ntshav cov paj hlwb, xws li kev ntxub ntxaug rau lub hlwb, tshee, thiab qee zaum suav, thiab qee zaus fara, qaug, thiab lwm yam. Cov pob khaus, khaus, mob taub hau, mob plab zom mov, cov tshuaj tsw qab, tsis muaj tshuaj tsw qab, tsis muaj tshuaj tsw qab, tsis muaj tshuaj pleev plab, tsis muaj tshuaj pleev plab, mob plab, mob plab, mob plab, mob siab ntxiv lossis txo ntshav siab .4.1.2, Hematuria, cov ntshav nce urea nitrogen, alopecia, txo cov ntshav tsawg dua piam thaj, Edema, peripheral tsis xis nyob, nce creinine, EOSinophilia, kev mob plab, phhlitis, thiab lwm yam .; Retinal detachility tuaj yeem pom hauv AIDS cov neeg mob nrog cytomegalovirus-muaj tus kab mob retinitis.
Qho piav
Contraindicated nyob rau hauv cov uas ua xua rau cov khoom no lossis acyclovir. Txwv tsis pub neeg neutropenia loj los yog tim tebcocytopenia raug txwv.