CAS: 113479-65-5 7 - Amino - 3 - Chloromethyl - 3 - Cephem - 4 - Carboxylic Acid P - Methoxybenzyl Ester Hydrochloride

Tseem ceeb Intermediate rau Cephalosporin Tshuaj tua kab mob: Raws li ib tug tseem ceeb precursor rau semi-synthetic cephalosporins, nws muaj peev xwm ua ke broad- spectrum tshuaj tua kab mob xws li cefepime thiab cefixime los ntawm nucleophilic hloov ntawm chloromethyl pawg thiab acylation ntawm cov amino pawg, uas yog siv los kho cov kab mob kab mob (xws li, kab mob ua pa thiab ua pa).

Raw Khoom rau Antibacterial Drug Structural Modification: Nws 3- pab pawg chloromethyl tso cai rau kev qhia txog cov khoom sib txawv (xws li, heterocycles, amino pawg) los txhim kho cov kab mob tua kab mob (xws li, txhawb kev ua haujlwm ntawm cov kab mob Gram-negative), kev ruaj ntseg, thiab cov tshuaj pharmacokinetic ntawm cov tshuaj, txhawb kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj tshiab cephalosporin.

Kev Cai Synthesis Intermediate hauv Pharmaceutical thiab Tshuaj Kev Lag Luam: Siv los ntawm cov chaw lag luam kws tshuaj rau kev kho kom haum xeeb ntawm cephalosporin tshuaj intermediates lossis cov qauv siv impurity, txhawb kev tswj cov tshuaj zoo, kev tshawb fawb ua ntej, thiab loj - teev cov txheej txheem tsim kom zoo.