Kev tshawb fawb yav dhau los ntawm cov tshuaj tshwj xeeb thiab tshuaj tiv thaiv rau COVID-19 feem ntau tau tsom mus rau tus kab mob nws tus kheej. Nrog rau kev hloov pauv sai thiab hloov pauv ntawm tus kab mob, qhov ua tau zoo ntawm cov kev kho mob no tau dhau los ua qhov hnyav zuj zus, thiab lawv txawm dhau los ua "tsuas yog versions" ntawm cov kev hloov pauv tshwj xeeb thiab raug rho tawm ntawm lub khw.
Tam sim no, cov tshuaj generic tsom rau txoj hauv kev ntawm tus kabmob coronavirus rau hauv cov hlwb xav tias yuav ua txhaum los ntawm qhov teeb meem no, paub txog "zoo ib yam" hauv kev tiv thaiv tus kabmob tshiab.
Thaum Lub Kaum Ob Hlis 5, 2022, cov kws tshawb fawb los ntawm University of Cambridge hauv UK tau luam tawm cov ntawv tshawb fawb txog FXR inhibition tuaj yeem tiv thaiv los ntawm SARS-CoV-2 kab mob los ntawm kev txo ACE2 hauv Xwm.
Cov txiaj ntsig tau pom ob yam: FXR tuaj yeem tswj ACE2 qhia; Kev thaiv txoj hauv kev no yuav pab txo tus kab mob COVID-19. Ursodeoxycholic acid, cov tshuaj siv dav siv hauv kev sim, yog qhov kev sib cav ntau.
Angiotensin-hloov enzyme 2 (ACE2) receptors tau nthuav tawm ntawm ntau lub xovtooj ntawm tes, thiab tus kabmob tshiab tshiab khi rau ACE2 los ntawm cov kab mob sib kis saum npoo av, yog li nkag mus rau cov hlwb thiab kis rau lawv. Vim tias cov receptor no tau nthuav tawm ntau hauv cov kab mob hauv cov kua tsib, cov kab mob tshiab tuaj yeem ua rau lub siab ua haujlwm tsis zoo.
Hauv ntau cov ntaub so ntswg cuam tshuam los ntawm COVID-19, suav nrog cov kab mob hauv plab hnyuv thiab ua pa, cov kws tshawb fawb tau pom tias FXR yog tus tswj hwm ncaj qha ntawm ACE2 transcription, nrog rau ursodeoxycholic acid rau kev kho mob gallstones thiab kab mob siab. Raws li FXR inhibitor, FXR inhibits ACE2 receptor qhia ntawm cov kua tsib lub hlwb los ntawm inhibiting qhov transcription FXR.
Hauv kev sim ua ntej, cov kws tshawb fawb tau muab cuaj hamsters ursodeoxycholic acid ntawm ib koob zoo ib yam li tib neeg; Rau lwm tus hamsters tau muab tshuaj ntsev. Ib lub lim tiam tom qab, cov hamsters tau muab tso rau hauv tib lub tawb li hamsters kis tus kabmob Delta tus kabmob sib txawv.
Cov hamsters tau euthanized plaub hnub tom qab. Pab neeg soj ntsuam lawv cov qauv ntsws. Tag nrho cov hamsters uas tau txais saline tau kis, tab sis tsuas yog ib feem peb ntawm cov uas tau txais ursodeoxycholic acid tau kis.
Thaum lub sij hawm sim, cov hamsters tau pub dawb rau zaub mov. Tab sis cov saline hamsters poob txog 9 feem pua ntawm lawv lub cev hnyav rau hnub plaub tom qab kis kab mob; Nyob rau hauv sib piv, cov hamsters nyob rau hauv lub ursodeoxycholic acid pab pawg neeg nce hnyav. Qhov no qhia tau tias kev kho ursodeoxycholic acid tuaj yeem txo qhov mob ntawm COVID-19.
Hauv lwm lo lus, nws nyuaj rau hais tias ursodeoxycholic acid tuaj yeem thaiv tus kab mob nkag mus rau 100 feem pua ntawm lub sijhawm, tab sis nws tuaj yeem thaiv tus kab mob nkag mus thiab txo tus kab mob mus rau qhov loj.
Tom ntej no, pab pawg tau sim ursodeoxycholic acid kho ntawm lub ntsws cov ntaub so ntswg pub los ntawm cov neeg tuaj yeem pab dawb. Cov kab mob ntsws no tswj lawv lub cev lub cev los ntawm kev txhawb nqa lub cev xws li lub tshuab ua pa.
Cov kws tshawb fawb tau txhaj ursodeoxycholic acid rau hauv ib lub ntsws thiab ntsev rau lwm qhov.
Tom qab 6 teev, lub ntsws ursodeoxycholic acid-kho tau pom ze li ntawm 50 feem pua txo qis hauv ACE2 qhia, tab sis tsis muaj kev hloov pauv hauv lub ntsws tswj. Cov txiaj ntsig tau pom tias lub ntsws txhaj nrog cov tshuaj tsis kis tus kab mob, thaum lwm lub ntsws yog.
Hauv yim yam kev noj qab haus huv, cov kws tshawb fawb kuj tau pom qhov txo qis ntawm ACE2 qhia ntawm lub qhov ntswg hauv cov neeg tuaj yeem pab dawb uas tau txais ursodeoxycholic acid.
Qhov tseem ceeb, tsis yog cov hamsters lossis cov neeg mob ntsws ntawm lub ntsws tsis muaj zog tiv thaiv kab mob. Tab sis piv nrog cov tshuaj tiv thaiv COVID-19, cov tshuaj xws li ursodeoxycholic acid yuav zoo dua rau cov neeg uas muaj kev tiv thaiv qis dua vim lawv cov txheej txheem sib txawv.
Astrazeneca's neutralizing antibody Evusheld yav dhau los tau siv los tiv thaiv COVID-19 kab mob hauv cov neeg uas muaj kev tiv thaiv qis thiab siv tsis tau cov tshuaj tiv thaiv COVID-19. Evushel txo tus kab mob lub peev xwm nkag mus thiab kis cov hlwb noj qab haus huv los ntawm kev khi rau ntau qhov chaw ntawm tus kabmob coronavirus spike protein. Thaum Lub Xya Hli, cov tshuaj tau pom zoo thawj zaug hauv Suav teb av loj ntawm kev sim -- nws tuaj yeem siv tau hauv Boao Lecheng International Medical Tourism Pilot Zone hauv Hainan.
Tab sis qhov ntawd tsis kav ntev. Tus kab mob no tau hloov zuj zus mus sai thiab qhov hloov pauv tshiab hloov pauv cov ntsiab lus ntawm cov kab mob sib kis, ua rau Evushel tsis zoo. Qhov no kuj yog ib qho kev mob tshwm sim, yog tias cov tshuaj tsim los rau tus kab mob, nws yuav ua tsis tau.
ACE2 yog lub qhov rooj rau cov kab mob nkag mus, thiab kaw nws txhais tau hais tias tus kab mob tsis tuaj yeem rov ua dua nws tus kheej, uas txhais tau hais tias muaj txoj hauv kev los tiv thaiv kev kis tus kab mob uas tsis nyob ntawm lub cev tiv thaiv kab mob hauv kev tawm tsam tus kabmob tshiab.
Yog li ursodeoxycholic acid puas tuaj yeem hloov cov tshuaj tiv thaiv? Cov kws tshawb fawb tau teb tias tam sim no cov tshuaj tiv thaiv yog txoj hauv kev zoo tshaj plaws los tiv thaiv COVID-19 kev kis tus kab mob, tab sis ob qho tib si tuaj yeem sib ntxiv kom txo tau kev pheej hmoo kis mob.
Cov kws tshawb fawb tam sim no tab tom mus tom ntej nrog kev sim tshuaj ntsuam xyuas seb puas muaj cov nyhuv ursodeoxycholic hauv cov tsiaj thiab organoids tuaj yeem siv rau hauv lub ntiaj teb tiag.