Boringer Ingelheim thiab Lilly (Eli Lilly) tsis ntev los no tau tshaj tawm cov txiaj ntsig zoo rau EMPA-KIDNEY 3 kev sim tshuaj ntsuam xyuas (NCT03594110) ntawm American Society of Nephrology Kidney Week (ASN Kedney Week) 2022. Cov ntaub ntawv qhia tau tias qhov kev sim mus txog qhov kawg ntawm lub ntsiab lus: Kev kho mob nrog SGLT2 inhibitor Jardiance (Suav lub npe lag luam, empagliflozin, Englegrizin) tau txais txiaj ntsig tseem ceeb rau lub raum thiab cov hlab plawv hauv cov neeg laus uas muaj kab mob raum (CKD). Cov ntaub ntawv tau luam tawm ib txhij nyob rau hauv cov ntawv xov xwm kho mob saum toj kawg nkaus thoob ntiaj teb, New England Journal of Medicine (NEJM), saib: Empagliflozin hauv Cov Neeg Mob Mob Raum Kab Mob.
EMPA-KIDNEY yog ntau lub teb chaws, randomized, ob qhov muag tsis pom kev, cov tshuaj placebo-tswj tshuaj ntsuam xyuas tsim los ntsuas qhov cuam tshuam ntawm Jardiance ntawm kev mob raum thiab kev tuag ntawm cov hlab plawv. Thawj qhov tshwm sim tau txhais tau tias yog lub sijhawm rau thawj qhov tshwm sim ntawm kev tuag ntawm cov hlab plawv lossis kev mob raum. Cov kab mob raum kev loj hlob tau txhais tau tias yog kab mob raum kawg (yuav tsum tau kho lub raum hloov, xws li kev lim ntshav lossis hloov lub raum), kev poob qis hauv eGFR mus rau<10ml in/1.73m2,="" renal="" death,="" and="" a="" sustained="" 40%="" decrease="" in="" egfr="" from="" randomization.="" key="" secondary="" outcomes="" include="" cardiovascular="" death="" or="" heart="" failure="" hospitalizations,="" all-cause="" hospitalization,="" and="" all-cause="" death.="" patients="" in="" the="" trial="" were="" randomized="" on="" a="" current="" standard="" of="" care="" basis,="" treated="" on="" jardiance="" 10mg="" or="">
EMPA-KIDNEY yog qhov loj tshaj plaws thiab dav tshaj plaws SGLT2 inhibitor sim rau CKD, suav nrog 6,609 tus neeg laus CKD cov neeg mob uas muaj ntau yam kab mob (nrog lossis tsis muaj ntshav qab zib, nrog lossis tsis muaj proteinuria), ntau tus neeg muaj cov kab mob ntau yam xws li mob plawv, lub raum lossis kab mob metabolic. Qhov kev sim tshuaj ntsuam xyuas lub raum thiab cov hlab plawv cov txiaj ntsig hauv cov neeg uas muaj qhov sib txawv ntawm CKD qhov hnyav.
Qhov kev sim EMPA-KIDNEY muab cov ntaub ntawv pov thawj tshiab rau cov neeg mob hauv tsev kho mob. Cov txiaj ntsig tau pom tias qhov kev sim tau mus txog qhov kawg ntawm qhov kawg: qhov nruab nrab ntawm kev rov qab los ntawm 2.0 xyoo, thiab kev kho Jardiance txo qis kev pheej hmoo ntawm kev mob ntshav qab zib nephropathy lossis mob plawv tuag piv nrog cov placebo; p<>
Kev loj hlob ntawm CKD ua rau kev lim ntshav lossis hloov lub raum, thiab yog li kev kho tshiab yuav tsum tau ceev nrooj los ncua kev kis kab mob hauv CKD. Cov txiaj ntsig ntawm EMPA-KIDNEY mus sib hais qhia tias Jardiance tuaj yeem tsim cov txiaj ntsig rau cov neeg laus uas muaj kev pheej hmoo ntawm CKD kev loj hlob, suav nrog cov neeg muaj lossis tsis muaj ntshav qab zib, nrog rau lub raum ua haujlwm. Los ntawm kev txo qis kev pheej hmoo ntawm kev mob raum lossis kab mob plawv tuag, Jardiance muaj peev xwm muaj txiaj ntsig zoo rau kev noj qab haus huv thoob ntiaj teb.
EMPA-KIDNEY yog thawj zaug SGLT2 inhibitor CKD sim los ua kom pom qhov txo qis hauv txhua qhov kev mus pw hauv tsev kho mob piv rau cov placebo (14 feem pua ;HR=0.86;95 feem pua CI:{{7} }. CKD ua rau tus neeg muaj kev pheej hmoo mus pw hauv tsev kho mob ob npaug thiab yog qhov ua rau tuag thoob ntiaj teb. Hauv Tebchaws Meskas, cov neeg mob CKD rau 35 feem pua - 55 feem pua ntawm tag nrho cov nqi kho mob.
Lwm cov ntsiab lus tseem ceeb thib ob, kev txo qis hauv HF mus pw hauv tsev kho mob, kev tuag ntawm cov hlab plawv, tag nrho cov kev tuag tsis yog qhov tseem ceeb, tab sis lub peev xwm los txheeb xyuas qhov no raug txwv los ntawm cov xwm txheej tau pom. Cov kev txo qis hauv kev pheej hmoo rau cov ntsiab lus kawg yog ua raws li cov pov thawj tag nrho los ntawm lwm qhov kev sim siab, qhov twg cov txiaj ntsig tau muaj txiaj ntsig zoo.
Cov ntaub ntawv kev nyab xeeb tag nrho hauv qhov kev sim no tau ua raws li cov kev tshawb fawb yav dhau los, lees paub qhov kev nyab xeeb zoo ntawm Jardiance.
Xib fwb Richard Haynes, tus thawj coj tshawb xyuas ntawm EMPA-KIDNEY sim, tau hais tias: "Kev sim EMPA-KIDNEY yog tsim los kom suav nrog ntau tus neeg mob ntau dua li yav dhau los. Cov neeg mob ntshav qab zib mellitus lossis qib protein ntau hauv cov zis, cov txiaj ntsig ntawm kev sim ua tau zoo niaj hnub no hauv cov pej xeem CKD dav qhia txog lub sijhawm los txhim kho kev kho tus kab mob no thiab tiv thaiv cov neeg mob los ntawm kev lim ntshav. "
Carinne Brouillon, tus thawj coj saib xyuas tshuaj rau Boehringer Ingelheim, tau hais tias: "Boehringer Ingelheim thiab Lilly Alliance zoo siab heev tias EMPA-KIDNEY mus sib hais muab lwm lub sijhawm tseem ceeb rau Jardiance. Cov ntaub ntawv niaj hnub no muab cov pov thawj tseem ceeb rau peb qhov kev kho mob, uas suav nrog Ntau tshaj 700,000 cov neeg laus uas muaj kab mob plawv, lub raum, thiab cov kab mob metabolic. Qhov kev sim EMPA-KIDNEY ntxiv dag zog rau lub luag haujlwm ntawm Jardiance hauv kev hloov pauv txoj kev sib cuam tshuam cov kab mob no. "
Cardio-lub raum-metabolic tej yam kev mob yog qhov ua rau tuag thoob ntiaj teb, ua rau muaj txog 20 lab tus neeg tuag txhua xyoo. EMPOWER Clinical Project, qhov dav thiab dav tshaj plaws ntawm tag nrho cov SGLT2 inhibitors, tab tom tshawb nrhiav qhov cuam tshuam ntawm Jardiance ntawm qhov chaw kho mob plawv thiab lub raum loj ntawm cov kab mob plawv cardiorenetabolic.Qhov project muaj cuaj qhov kev sim tshuaj thiab ob qhov kev tshawb fawb pov thawj hauv ntiaj teb. Ntau tshaj 700,000 cov neeg mob laus thoob ntiaj teb tau koom nrog qhov kev pab cuam hauv kev sim tshuaj.
Jardiance (O'Tang Jing, Engliazin) yog qhov ncauj, ib hnub ib zaug, xaiv SGLT-2 inhibitor. SGLT-2 inhibitors tau pom tias thaiv cov reabsorption ntawm qabzib hauv lub raum, tso cov piam thaj ntau dhau rau hauv lub cev kom txo cov ntshav qabzib, thiab cov nyhuv hypoglycemic yog ywj pheej ntawm kev ua haujlwm ntawm tes thiab insulin tsis kam. Ntxiv nrog rau nws cov nyhuv hypoglycemic meej, cov tshuaj muaj cov txiaj ntsig ntxiv xws li txo qhov hnyav thiab txo qhov kev pheej hmoo ntawm cov kab mob plawv.
Jardiance tau pom zoo rau xyoo 2014 thiab tau pom zoo rau peb qhov kev qhia: (1) rau kev kho mob ntawm cov neeg mob ntshav qab zib hom 2; (2) rau cov neeg mob uas muaj kab mob plawv, txo qis kev pheej hmoo ntawm cov hlab plawv tuag, thiab (3) txo qis kev pheej hmoo ntawm cov hlab plawv tuag thiab lub plawv tsis ua haujlwm hauv cov neeg mob plawv tsis ua haujlwm (HF).