Kev raug mob ntawm paj hlwb tuaj yeem ua rau lub paj hlwb tsis ua haujlwm tas mus li vim muaj kev txwv axonal regeneration, thiab kev raug mob-dependent thiab tsis muaj kev ywj pheej mechanisms tuaj yeem muab kev nkag siab tseem ceeb rau kev tsim kho neuronal. Txawm li cas los xij, qhov sib xws uas txhawb nqa kev tsim kho neural tseem tsis pom, thiab kev sib piv cov kev soj ntsuam ntawm cov ntaub ntawv transcriptomic ntsig txog cov peev txheej ntawm cov neurons qhia tias circadian rhythms yuav yog txoj hauv kev zoo tshaj plaws. Hauv kev tshawb fawb tsis ntev los no tau tshaj tawm hauv phau ntawv xov xwm thoob ntiaj teb Cell Metabolism hu ua "Lub sij hawm circadian moos tunes axonal regeneration," cov kws tshawb fawb los ntawm University of Geneva thiab lwm lub koom haum hauv Switzerland pom tias Lub moos circadian tuaj yeem tswj hwm axonal regeneration thiab kho.
Nyob rau hauv tsab xov xwm, cov kws tshawb fawb pom tau hais tias nyob rau hauv tus nas qauv ntawm sciatic paj hlwb raug mob, dorsal cag ganglia (DRG) sensory neurons muaj ib tug endogenous molecular moos uas yuav optimize axonal regeneration; Tsis tas li ntawd, lawv kuj tau piav qhia tias kev siv cov tshuaj siv sijhawm xws li lithium, uas tam sim no siv rau hauv kev kho mob rau kev kho mob ntawm tib neeg lub paj hlwb, tuaj yeem txhawb nqa axonal regeneration. Cov txiaj ntsig ntawm txoj kev tshawb no tuaj yeem muab cov kws tshawb fawb txog lub sijhawm los ua kom zoo dua qub ntawm axons. Cov kev tshawb pom no tuaj yeem ua rau txoj hauv kev rau cov kws tshawb fawb los siv cov kev kho mob ntsig txog moos thiab cov tswv yim kho mob raws sij hawm los kho cov neeg mob peripheral paj hlwb (PNS, Peripheral Nervous System) raug mob.
Lub moos lom neeg tuaj yeem tswj hwm lub cev axonal regeneration thiab kho kev puas tsuaj.
Duab credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.10.012
Peb qhov kev tshawb pom qhia tias lub moos lom neeg tuaj yeem tswj hwm axonal regeneration, thiab peb tuaj yeem coj mus rau hauv cov txheej txheem no los ntawm kev hloov pauv kev siv lithium (ib lub sijhawm siv tshuaj siv los kho cov kab mob neurological) los txhawb kev tsim kho axonal; Dab tsi ntxiv, qhov kev tshawb pom kuj qhia txog kev siv chronotherapy thiab neurorehabilitation los txhim kho lub tswv yim ntawm kev kho neural hauv lub cev.
Ua ke, cov txiaj ntsig ntawm daim ntawv no qhia tias lub moos molecular yuav tuaj yeem txhim kho lub peev xwm rov ua dua tshiab ntawm kev hnov mob neurons, thiab cov kws tshawb fawb kuj tau hais tias cov tebchaw cuam tshuam rau lub moos txoj hauv kev tuaj yeem ua txoj hauv kev tshiab los kho thiab txhawb kev kho. kev raug mob neurological hauv lub cev.