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Lub npe
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4-((2S,4S)-4-ethoxy-1-((tert-butoxycarbonyl-5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid
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Synonyms
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4 - ((2S,4S) - 4 - ethoxy - 1 - ((tert - butoxycarbonyl - 5 - methoxy - 7 - methyl) piperidin - 2 - yl) methyl) benzoic acid
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CAS Nr.
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2803364 - 77 - 2
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MF
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C₃₀H₃₈N₂O₆
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MW
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522.64
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Qhov tshwm sim
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Feem ntau yog dawb mus rau dawb crystalline hmoov (nyob rau hauv siab purity);
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Solubility
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Yooj yim soluble hauv cov kuab tshuaj organic xws li dichloromethane, ethyl acetate, methanol, acetonitrile; me ntsis soluble hauv dej (dej solubility tuaj yeem txhim kho los ntawm kev tsim ntsev ntawm pawg carboxyl, piv txwv li, cov tshuaj tiv thaiv nrog lub hauv paus los tsim sodium ntsev);
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Melting point
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165-170℃(ib txwm melting ntau rau chiral intermediates, yuav txawv me ntsis nrog purity);
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Kev ruaj ntseg
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Stable under neutral/weakly acidic conditions; Boc protecting group can be removed under strongly acidic conditions (e.g., concentrated hydrochloric acid, trifluoroacetic acid); decomposition may occur at high temperature (>200 degree).
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Kev siv
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Cov khoom siv tseem ceeb rau Ivacaftor synthesis: Raws li qhov tseem ceeb chiral nruab nrab hauv kev tsim cov Ivacaftor, cov tshuaj tsom rau kev kho mob cystic fibrosis (CF), nws cov qauv tshwj xeeb chiral ua haujlwm tseem ceeb ntawm cov tshuaj. Nws tsim cov qauv ua tiav ntawm Ivacaftor los ntawm cov tshuaj tiv thaiv nrog lwm cov molecular fragments, thiab nws cov purity siab (tshwj xeeb tshaj yog chiral purity) yog qhov tseem ceeb rau kev ua kom cov tshuaj zoo, ua tau zoo, thiab kev nyab xeeb.
Cov cuab yeej siv tshuaj R & D thiab kev ua kom zoo tshaj plaws: Kev ua haujlwm raws li tus qauv chiral rau kev txhim kho cov txheej txheem Ivacaftor, kev txhim kho tshuaj generic, thiab kev tsim kho tshiab CF. Nws kuj tseem txhawb nqa qhov ntsuas - nce kev txheeb xyuas cov txheej txheem hluavtaws, qhov twg nws cov txheej txheem ruaj khov, tawm los, thiab tus nqi cuam tshuam ncaj qha rau kev tsim khoom lag luam ntawm Ivacaftor.
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Cim npe nrov: cas:2803364-77-2 4-((2s,4s)-4-ethoxy-1-((tert-butoxycarbonyl-5-methoxy-7-methyl-1h-indol-4-yl)methyl)piperidin-2-yl)benzoicacid, Suav teb, manufacturers, lwm tus neeg, Hoobkas, kev cai, lag luam wholesale
